Iran- Premature Coronary Artery Disease
I-PAD
Determining the Prevalence of Premature Coronary Heart Disease and it's Risk Factors According to Different Ethnicities and Religions in Iran and Developing a Biobank for Genetic and Epigenetic Studies
1 other identifier
observational
5,000
1 country
1
Brief Summary
This case-control study will be conducted all over the country (in Persian, Kurd, Azari, Arab, Lor, Bakhtiari, Baluch, Turkman, Qashqai, Gilak and in Muslims, Christians, Jewish, and Zoroastrian). the investigators intend to recruit patients (men 60≥ years of age and women 70≥ years of age) who underwent coronary angiography. Patients with coronary artery stenosis more than 75% (or left-main stenosis more than 50%) are defined as case group and patients with normal angiography are considered as the control group. at the same time, the prevalence of premature coronary artery disease in patients with positive angiography will be calculated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2018
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 25, 2018
CompletedFirst Submitted
Initial submission to the registry
January 11, 2020
CompletedFirst Posted
Study publicly available on registry
June 4, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 30, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2020
CompletedJune 4, 2020
May 1, 2020
2 years
January 11, 2020
May 29, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Odds ratio
Odds ratio for life style risk factors among different ethnicities and religions
2018 to 2020
Study Arms (2)
Case
Patients with coronary artery stenosis more than 75% (or left-main stenosis more than 50%) are defined as case group
Control
Patients with normal angiography are considered as control group.
Eligibility Criteria
patients with documented coronary angiography
You may qualify if:
- Men and women less than 60 and 70 years respectively
- Ethnicity
- Coronary artery stenosis more than 75% (or left-main stenosis more than 50%) or patients with normal angiography
You may not qualify if:
- patients with past medical history of CABG or documented coronary stenosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Isfahan Cardiovascular Research Institute
Isfahan, 8158388994, Iran
Biospecimen
Blood samples will be evaluated for fasting blood sugar and lipid profiles. All biological samples (serum, plasma, buffy coat, whole blood, urine, stool, and saliva) will be transferred to the central lab of the Isfahan Cardiovascular Research Institute to create a biobank (-80 c) for future genetic and epigenetic studies.
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr. Ehsan Zarepur (Cardiology resident, PhD candidate)
Study Record Dates
First Submitted
January 11, 2020
First Posted
June 4, 2020
Study Start
August 25, 2018
Primary Completion
August 30, 2020
Study Completion
December 30, 2020
Last Updated
June 4, 2020
Record last verified: 2020-05