Anti-neutrophil Cytoplasmic Antibody in Interstitial Lung Disease.

NCT04413149 | Completed Results DMC

• 1 other identifier: PUMCH-ANCA-positive ILD
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the clinical features and long-term outcome of anti-neutrophil cytoplasmic antibody (ANCA)-positive interstitial lung disease (ILD) and assess the difference between microscopic polyangiitis (MPA) associated ILD and isolated ANCA-positive idiopathic interstitial pneumonia.

Conditions

Interstitial Lung Disease; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Keywords

Interstitial Lung Disease; Anti-Neutrophil Cytoplasmic Antibody; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Outcome Measures

Primary Outcomes (2)

• Death From All Causes

  Death from all causes Retrieved from medical records.

  From baseline until the date of death from all cause, up to 5 years

• Number of Patients Who Underwent Lung Transplantation

  Number of patients who underwent lung transplantation Retrieved from medical records.

  From baseline until the date of transplantation, up to 5 years

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Interstitial lung disease patients with anti-neutrophil cytoplasmic antibody.

You may qualify if:

• Males and females
• Aged from 18 to 85 years with informed consent
• Have a diagnosis of ILD based on clinical symptoms and radiologic features, with or without histopathologic results
• Have available ANCA testing results during the first visit and follow-up period

You may not qualify if:

• Connective tissue disease associated ILD
• ILD induced by drug, environment, or occupational exposure
• Hypersensitivity pneumonitis and sarcoidosis

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking Union Medical College Hospital

Beijing, Beijing Municipality, 100730, China

Location

Related Publications (1)

• Sun X, Zhu W, Zhou C, Xue P, Li Z, Zhang W, Zhao J, Zhang T, Peng M, Shi J, Wang C. Clinical significance of anti-neutrophil cytoplasmic antibody in idiopathic interstitial pneumonia: a retrospective observational study. BMC Pulm Med. 2025 May 29;25(1):271. doi: 10.1186/s12890-025-03736-4.

  PMID: 40442650 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Lung Diseases, Interstitial; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Systemic Vasculitis; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Skin Diseases, Vascular; Skin Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Limitations and Caveats

Selection bias is possible due to its retrospective nature.

Results Point of Contact

• Title: Dr. Shi Juhong
• Organization: Peking Union Medical College Hospital

Shijh@pumch.cn

+86-13701178492

Study Officials

• Juhong Shi, M.D

  Peking Union Medical College Hospital

  STUDY CHAIR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2020
• First Posted: June 2, 2020
• Study Start: April 1, 2014
• Primary Completion: April 1, 2019
• Study Completion: April 1, 2020
• Last Updated: May 17, 2024
• Results First Posted: May 17, 2024

Record last verified: 2024-05

Locations

CN (1)