Glucose Metabolism After Partial Pancreatectomy

NCT04409171 | Completed DMC

• 1 other identifier: SNUBH-GS-HBP6
• Study Type: observational
• Target: 224
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a single center observational study to assess alteration of glucose metabolism after pancreatectomy.

Conditions

Pancreatectomy; Hyperglycemia; Diabete Mellitus

Keywords

Pancreatectomy; Diabetes Mellitus; pancreaticoduodenectomy

Outcome Measures

Primary Outcomes (2)

• incidence & risk factors of new-onset DM

  incidence \& risk factors of new onset DM after pancreatectomy

  at 1 year

• incidence & risk factors of worsened DM

  incidence \& risk factors of worsened DM after pancreatectomy

  at 1 year

Secondary Outcomes (1)

• characteristics of new-onset and worsened DM

  1 year

Study Arms (2)

PD

pancreaticoduodenectomy

Diagnostic Test: oral glucose tolerance test

DP

distal pancreatectomy

Diagnostic Test: oral glucose tolerance test

Interventions

oral glucose tolerance test DIAGNOSTIC_TEST

DP; PD

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients receiving partial pancreatectomy

You may qualify if:

• partial pancreatectomy

You may not qualify if:

• total pancreatectomy
• incomplete testing
• follow-up loss
• death within 1 year

Sponsors & Collaborators

• Seoul National University Hospital: lead

Related Publications (2)

• Lee BW, Kang HW, Heo JS, Choi SH, Kim SY, Min YK, Chung JH, Lee MK, Lee MS, Kim KW. Insulin secretory defect plays a major role in the development of diabetes in patients with distal pancreatectomy. Metabolism. 2006 Jan;55(1):135-41. doi: 10.1016/j.metabol.2005.08.005.

  PMID: 16324932 BACKGROUND

• Hwang HK, Park J, Choi SH, Kang CM, Lee WJ. Predicting new-onset diabetes after minimally invasive subtotal distal pancreatectomy in benign and borderline malignant lesions of the pancreas. Medicine (Baltimore). 2017 Dec;96(51):e9404. doi: 10.1097/MD.0000000000009404.

  PMID: 29390555 BACKGROUND

MeSH Terms

Conditions

Hyperglycemia; Diabetes Mellitus

Interventions

Glucose Tolerance Test

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Endocrine; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: May 26, 2020
• First Posted: June 1, 2020
• Study Start: September 1, 2015
• Primary Completion: December 31, 2018
• Study Completion: January 31, 2020
• Last Updated: June 1, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share