Epidemiology of Acute Kidney Injury in COVID19 Disease in United Kingdom

NCT04407156 | Completed

• 1 other identifier: UHDB/2020/050
• Study Type: observational
• Target: 724
• Locations: 1 country
• Sites: 1

Brief Summary

Severe Acute respiratory syndrome coronovirus (SARS-CoV-2) was first described in Wuhan in December 2019. It quickly spread to rest of the world and was declared pandemic by World health organisation. Initial case series focused on lung involvement in the form alveolar haemorrhages and respiratory failure. However, subsequently, there have been reports of kidney involvement resulting in severe acute kidney injury. However, the reported incidence from Chinese data has been less than 5% and detailed epidemiology of AKI in COVID-19 disease is lacking.

Conditions

COVID; AKI

Outcome Measures

Primary Outcomes (1)

• Incidence of Acute kidney injury in COVID-19

  This is the proportion of patients with Acute kidney injury in COVID-19

  7 days

Secondary Outcomes (1)

• All-cause mortality in AKI patients

  7 days

Interventions

acute kidney injury OTHER

AKI in COVID positive cases

Eligibility Criteria

• Age: 18 Years - 110 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population is hospitalised patients suspected to have SARS CoV-2 infection

You may qualify if:

• All patients who are admitted to the hospital with suspected COVID-19 infection between 1st March 2020 and 8th May 2020 and who meet following criteria will be included
• Adult patients greater or equal to 18 years of age.
• Swab results available for SARS CoV-19
• Patients admitted to the hospital as per the national screening criteria

You may not qualify if:

• The following patients will be excluded from the study
• Paediatric patients as defined by age of \<18 years of age
• Swab results which are awaited
• Patients on haemodialysis or peritoneal dialysis

Sponsors & Collaborators

• University Hospitals of Derby and Burton NHS Foundation Trust: lead

Study Sites (1)

Derby Hospital NHS Foundation Trust

Derby, Derbyshire, DE22 3NE, United Kingdom

Location

Related Publications (1)

• Kolhe NV, Fluck RJ, Selby NM, Taal MW. Acute kidney injury associated with COVID-19: A retrospective cohort study. PLoS Med. 2020 Oct 30;17(10):e1003406. doi: 10.1371/journal.pmed.1003406. eCollection 2020 Oct.

  PMID: 33125416 DERIVED

Study Officials

• Nitin V Kolhe, MD

  University Hospitals of Derby and Burton

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 6, 2020
• First Posted: May 29, 2020
• Study Start: June 1, 2020
• Primary Completion: June 7, 2020
• Study Completion: July 20, 2020
• Last Updated: September 9, 2020

Record last verified: 2020-09

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)