NCT04406090

Brief Summary

About 5% of COVID-19 patients may present symptoms related to acute ischemic stroke (AIS). Treatment-management and outcomes related to mechanical thrombectomy (MT) for COVID-19 infected patients harboring large vessel occlusion is largely unknown. This multicentric study aims to investigate morbidity, mortality and neurological outcomes after MT performed in patients with COVID-19 infection.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
50

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Apr 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2020

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

May 26, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 28, 2020

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2020

Completed
Last Updated

July 29, 2020

Status Verified

May 1, 2020

Enrollment Period

3 months

First QC Date

May 26, 2020

Last Update Submit

July 28, 2020

Conditions

Ischemic StrokeCovid 19

Keywords

Acute ischemic stroke related to large vessel occlusionMechanical TrombectomyCOVID-19SARS-CoV-2

Outcome Measures

Primary Outcomes (2)

  • Intrahospital mortality

    Intrahospital mortality after MT for COVID-19 infected patients harboring large vessel occlusion

    1day

  • short-term morbidity

    short-term morbidity after MT for COVID-19 infected patients harboring large vessel occlusion

    1 day

Secondary Outcomes (1)

  • Angiographic success

    1 day

Interventions

Mechanical TrombectomyOTHER

Stent retriever for treatment of cerebral arterial occlusions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients \>18 years infected with the SARR-CoV-2, presenting an acute ischemic stroke, and eligible to be treated with mechanical thrombectomy (based on the current guide-lines)

You may qualify if:

  • \- Patients \>18 years infected with the SARR-CoV-2 with acute ischemic stroke, and eligible for mechanical thrombectomy (based on the current guide-lines)

You may not qualify if:

  • \- Patients \<18 years ; no eligibility to mechanical thrombectomy ; absence of diagnosis of COVID-19

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Uhmontpellier

Montpellier, 34295, France

Location

Related Publications (1)

  • Cagnazzo F, Piotin M, Escalard S, Maier B, Ribo M, Requena M, Pop R, Hasiu A, Gasparotti R, Mardighian D, Piano M, Cervo A, Eker OF, Durous V, Sourour NA, Elhorany M, Zini A, Simonetti L, Marcheselli S, Paolo NN, Houdart E, Guedon A, Ligot N, Mine B, Consoli A, Lapergue B, Cordona Portela P, Urra X, Rodriguez A, Bolognini F, Lebedinsky PA, Pasco-Papon A, Godard S, Marnat G, Sibon I, Limbucci N, Nencini P, Nappini S, Saia V, Caldiera V, Romano D, Frauenfelder G, Gallesio I, Gola G, Menozzi R, Genovese A, Terrana A, Giorgianni A, Cappellari M, Augelli R, Invernizzi P, Pavia M, Lafe E, Cavallini A, Giossi A, Besana M, Valvassori L, Macera A, Castellan L, Salsano G, Di Caterino F, Biondi A, Arquizan C, Lebreuche J, Galvano G, Cannella A, Cosottini M, Lazzarotti G, Guizzardi G, Stecco A, Tassi R, Bracco S, Bianchini E, Micieli C, Pascarella R, Napoli M, Causin F, Desal H, Cotton F, Costalat V; ET-COVID-19 Study Group*. European Multicenter Study of ET-COVID-19. Stroke. 2021 Jan;52(1):31-39. doi: 10.1161/STROKEAHA.120.031514. Epub 2020 Nov 23.

    PMID: 33222617DERIVED

Biospecimen

Retention: NONE RETAINED

NC

MeSH Terms

Conditions

Ischemic StrokeCOVID-19

Condition Hierarchy (Ancestors)

StrokeCerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesPneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronavirus InfectionsCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Federico Cagnazzo, MD PhD

    UH Montpellier

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 26, 2020

First Posted

May 28, 2020

Study Start

April 1, 2020

Primary Completion

June 30, 2020

Study Completion

June 30, 2020

Last Updated

July 29, 2020

Record last verified: 2020-05

Locations

FR(1)