NCT04405427

Brief Summary

The investigators will conduct a single-center, and randomized controlled cases study. A total of 120 participants with insomnia will be enrolled. The aim of the study is to compare the therapeutic effect between head-acupoints acupuncture and body-acupoints acupuncture on Insomnia.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Aug 2020

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 24, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 28, 2020

Completed
2 months until next milestone

Study Start

First participant enrolled

August 7, 2020

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 31, 2021

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2021

Completed
Last Updated

August 25, 2020

Status Verified

May 1, 2020

Enrollment Period

10 months

First QC Date

May 24, 2020

Last Update Submit

August 24, 2020

Conditions

Keywords

acupunctureprimary insomnia

Outcome Measures

Primary Outcomes (3)

  • Changes of The Epworth sleepiness scale (ESS)

    The Epworth sleepiness scale (ESS) containing eight items that ask for self-reported disclosure of the expectation of "dozing" in a variety of situations. A sum of responses is calculated for a total score ranging from 0 to 24, higher scores mean a worse. outcome.

    Baseline week 0, week 2, week 4 & 2 weeks post-tx (week 6)

  • Changes of The HADS(The Hospital Anxiety and Depression Scale)

    The Hospital Anxiety and Depression Scale is a 14-items self-administered questionnaire, the scores ranged from 0 to 21 for anxiety and 0 to 21 for depression, higher scores mean a worse outcome.

    Baseline week 0, week 2, week 4 & 2 weeks post-tx (week 6)

  • Changes of The PSQI(Pittsburgh Sleep Quality Index)

    The 19 questions are combined into seven clinically-derived component scores, each weighted equally from 0-3. The seven component scores are added to obtain a global score ranging from 0-21, with higher scores indicating worse sleep quality.

    Baseline week 0, week 2, week 4 & 2 weeks post-tx (week 6)

Secondary Outcomes (3)

  • HRV(Heart rate viability)

    Baseline week 0, week1, week 2, week 3, week 4 and week 6; and 30 minutes before and 60 minutes after acupuncture through study completion, an average of 1 year.

  • actigraphy (3-day)

    Baseline week 0, week 2, week 4 & 2 weeks post-tx (week 6)

  • sleep diary

    Baseline week 0, week 2, week 4 & 2 weeks post-tx (week 6)

Study Arms (2)

head acupoints acupuncture

EXPERIMENTAL

Acupuncture treatment for 12 acupoints on both sides of the head

Procedure: head acupoints acupuncture

body acupoints acupuncture

ACTIVE COMPARATOR

Acupuncture treatment for 12 acupoints on both sides of the body

Procedure: body acupoints acupuncture

Interventions

The participants will undergo GV20, EX-HN-1, GV21, GV22, GV23, GV24, GV29, and GB13 head acupoints aupunture treatment 3 times/ 1 week for 4 weeks.

head acupoints acupuncture

The participants will undergo HT7, PC6, SP6, ST36, KI3, and LR3 body acupoints acupunture treatment 3 time/1 week for 4 weeks.

body acupoints acupuncture

Eligibility Criteria

Age20 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • aged 20\~70 years,
  • met the diagnostic criteria of insomnia according to the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition, DSM-V)
  • experienced insomnia at least three times a week for more than a month
  • voluntarily agreed with the investigation and signed a written informed con- sent form before the clinical trial started.

You may not qualify if:

  • a pregnant or lactating woman
  • the patient's insomnia is caused by mental disorders other than mild anxiety,
  • the patient has serious cardiovascular, liver, kidney or hematopoietic system disease
  • the patient's insomnia is caused by nervous system disease (eg, stroke, Parkinson's Disease)
  • the patient has taken Chinese herbs and herbal formulas for insomnia two weeks before the trial
  • the patient with cardiac pacemaker
  • the patient does not want to wear portable physiological signal recording device (SOMNOwatchTM) and handheld ECG monitor
  • the patient has a history of sleep apnea

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Chang Gung Memorial Hospital

Keelung, Taiwan

RECRUITING

MeSH Terms

Conditions

Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Sleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesMental Disorders

Study Officials

  • Lee Tsai-Jean, MD

    Chang Gung Memorial Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Lee Tsai-Jean, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 24, 2020

First Posted

May 28, 2020

Study Start

August 7, 2020

Primary Completion

May 31, 2021

Study Completion

August 31, 2021

Last Updated

August 25, 2020

Record last verified: 2020-05

Data Sharing

IPD Sharing
Will not share

There will be a research number representing the identity. This number will not display the name, identification number, and address. For the results and diagnosis of the visit, the research host will maintain a confidential attitude and carefully maintain the privacy. If research results are published, the identity will remain confidential. Please also understand that if the participant signs the consent form, the participant agrees that the visit record can be directly reviewed by the monitor, auditor, research ethics committee and the competent authority to ensure that the research process and data comply with relevant laws and regulations. These people also promise not to violate the confidentiality of your identity.

Locations