Dynamic 4DCT to Examine Wrist Carpal Mechanics

NCT04402502 | Completed

• 1 other identifier: 5147
• Study Type: interventional
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

Osteoarthritis can develop after an injury like a broken bone. Problems with how the bones line up can lead to abnormal loading which will destroy the cartilage that covers and protects the bones. Once this happens, patients experience substantial pain and disability. Researchers and doctors use planar x-rays to evaluate joints; but these are not always precise and are limited to two dimensions. Three-dimensional (3D) computed tomography (CT) can be used to look at the joints of the wrist in three dimensions, but is limited to static frames. Symptoms arising from joint instability often occur when the wrist is moving and when it is performing a functional task (opening a jar). Four dimensional computed tomography (4DCT) can detect dynamics changes in the small structures of the wrist with high temporal and spatial resolution. This novel imaging techniques provides a movie of bones in the wrist, in 3D, while in the scanner. In this proposal, the investigator's will use 4DCT and look at how joint alignment of the distal radius effects the joints in the wrist, and investigate how it relates to patient's function, description of pain and the presence of Osteoarthritis 10 years following fracture. This imaging will drive safer clinical research and practice and will develop tools that predict the risk of developing arthritis that will help doctors determine when surgery is necessary to prevent arthritis of the hand and wrist, and pain and disability.

Conditions

Osteoarthritis

Keywords

3D Ultrasound Monitoring

Outcome Measures

Primary Outcomes (1)

• Hand Joint Spacing

  To measure joint spacing of the hand in a 3D ultrasound image

  3 years

Study Arms (1)

Healthy Population

EXPERIMENTAL

Healthy Individuals with no presence of neurological disorders, rheumatoid arthritis or comorbid health conditions, and are not pregnant.

Device: Ultrasound Imaging

Interventions

Ultrasound Imaging DEVICE

The participant will go to the Rheumatology clinic (St. Joseph's Hospital) and have 3D hand ultrasound performed on their hands.

Healthy Population

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• fluent in English, capacity to provide consent,
• over the age of 18 years old, with no previous injury to either hand or wrist

You may not qualify if:

• pregnancy and presence of neurological disorders, rheumatoid arthritis or comorbid health conditions that preclude completion of study measures

Sponsors & Collaborators

• Western University, Canada: lead

Study Sites (1)

St. Joseph's Hospital

London, Ontario, Canada

Location

MeSH Terms

Conditions

Osteoarthritis

Interventions

Ultrasonography

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Healthy Population

Study Record Dates

• First Submitted: May 20, 2020
• First Posted: May 26, 2020
• Study Start: September 26, 2018
• Primary Completion: September 24, 2021
• Study Completion: February 2, 2022
• Last Updated: August 11, 2022

Record last verified: 2022-08

Locations

CA (1)