Stroke Prevention and Rhythm Control Therapy STEEER-AF
STEEER-AF
1 other identifier
interventional
1,732
6 countries
70
Brief Summary
A prospective trial with hospitals/health centres across 6 different European countries, being randomised to either a structured education programme as the intervention or no additional education as the control. To determine whether a comprehensive educational programme for healthcare professionals will increase the rate of appropriate stroke prevention and rhythm control therapy in patients with atrial fibrillation (AF) and adherence to Guidelines.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable atrial-fibrillation
Started Dec 2021
Typical duration for not_applicable atrial-fibrillation
70 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 14, 2020
CompletedFirst Posted
Study publicly available on registry
May 20, 2020
CompletedStudy Start
First participant enrolled
December 29, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 10, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2025
CompletedJune 20, 2024
June 1, 2024
2 years
May 14, 2020
June 18, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Adherence to ESC Guidelines in Atrial Filbrillation
Full adherence to guidelines for stroke prevention rhythm control therapy
25 months per centre
Secondary Outcomes (1)
Proportion of relevant guidelines adhered to
25 months per centre
Other Outcomes (1)
Process outcome
25 months per centre
Study Arms (2)
Intervention arm
EXPERIMENTALA 16-week blended learning programme targeting stroke prevention and rhythm control therapy at the healthcare professional level, with controlled assessments, a commitment to change plan, and reinforcement actions
Control arm
OTHERNo added education of healthcare professionals
Interventions
Randomization between two groups at site level. One cluster with education and one without.
Eligibility Criteria
You may qualify if:
- Patients diagnosed with AF
- Patient consents to data collection at baseline and follow-up.
You may not qualify if:
- Patients aged under 18 years of age,
- Pregnant or planning pregnancy,
- Participating in another clinical trial of an investigational medicinal product or device,
- Life expectancy of less than 2 years.
- Patient assessment: Baseline (time of recruitment) and at follow-up routine appointment (6-9 months), plus remote follow-up at 18 months.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- European Society of Cardiologylead
- University of Birminghamcollaborator
Study Sites (70)
CHU Rennes
Rennes, 'Ille-et-Vilaine, Brittany, 35000, France
CHU La Timone
Marseille, Bouches-du-Rhône, 13005, France
CHU Dijon - Hôpital du Bocage
Dijon, Burgundy, 21000, France
Hôpital Cardiologique du Haut-Lévèque
Pessac, Gironde, Nouvelle-Aquitaine, 33600, France
CHU Dupuytren
Limoges, Haute-Vienne, 87000, France
CHU Nancy, Hôpitaux de Brabois
Nancy, Meurthe-et-Moselle (Lorraine), 54500, France
CHU Rouen
Rouen, Normandy, 76000, France
CHU Rangueil
Toulouse, Occitanie, Haute-Garonne, 31400, France
CHU Poitiers
Poitiers, Poitou-Charentes, 86000, France
CHU Aix en Provence
Aix-en-Provence, Provence-Alpes-Côte d'Azur Region, 13100, France
Centre Hospitalier de Pau
Pau, Pyrénées-Atlantiques, 64046, France
CHI Toulon La Seyne-sur-Mer Sainte Musse
Toulon, Var, 83100, France
Hôpital Henri Mondor (APHP)
Créteil, Île-de-France Region, 94000, France
CHU Pitié-Salpetrière
Paris, Île-de-France Region, 75013, France
Centre Cardiologique du Nord (CCN)
Saint-Denis, Île-de-France Region, 93200, France
University Hospital Würzburg
Würzburg, Bavaria, 97080, Germany
Segeberger Kliniken GmbH
Bad Segeberg, chleswig-Holstein, 23795, Germany
Herzzentrum Niederrhein Krefeld
Krefeld, North Rhine-Westphalia, 47805, Germany
Heart Centre Bad Neustadt
Neustadt, Rhineland-Palatinate, 97616, Germany
Praxisklinik Herz Und Gefässe
Dresden, Saxony, 01099, Germany
Heart Center Leipzig, University of Leipzig
Leipzig, Saxony, 04289, Germany
Herz Riesa
Riesa, Saxony, 01587, Germany
Asklepios Klinik St. Georg
Hamburg, 20099, Germany
Heart Center University Hamburg
Hamburg, 20251, Germany
Medizinische Hochschule Hannover, MHH
Hanover, 30159, Germany
Universitätsklinikum Schleswig-Holstein Lübeck
Lübeck, 23562, Germany
Federico II University Hospital
Naples, Campania, 80138, Italy
S Orsola-Malpighi University Hospital
Bologna, Emilia-Romagna, 40138, Italy
Sant'Anna University Hospital of Ferrara
Ferrara, Emilia-Romagna, 44100, Italy
Policlinico di Modena, University of Modena and Reggio Emilia
Modena, Emilia-Romagna, 41100, Italy
Cardiologia Orvieto
Orvieto, Terni, 05018, Italy
University of Florence & AOU Careggi
Florence, Tuscany, 50121, Italy
Clinica Aritmologica, Universita Politecnica delle Marche
Ancona, 60100, Italy
Cardiology Unit Borgo San Lorenzo and Serristori
Florence, Italy
Toruń Hospital
Torun, Vistula Rive, 87-100, Poland
District Chojnice Hospital
Chojnice, 89-600, Poland
Scanmed Cardiology Center
Ełk, 19-302., Poland
Centrum Opieki Medycznej w Jaroslawiu
Jarosław, 37-500, Poland
Polikliniką SPZOZ w Lublinie
Lublin, 20-400, Poland
Przasnysz
Przasnysz, 06-300, Poland
Pułtusk
Pułtusk, 06-100, Poland
Siedlce 2 Hospital
Siedlce, 08-119, Poland
Wojewódzki Szpital Specjalistyczny nr 5 im
Sosnowiec, 41-200, Poland
Szpital Wojewodzki in Sw. Lukasza / Regional Specialist Hospital
Tarnów, 33-100, Poland
Wegrow Hospital
Węgrów, 07-100, Poland
Lukow
Łuków, 21-400, Poland
Hospital Universitario Puerta del Mar
Seville, Andalusia, 11009, Spain
Virgen del Rocio University Hospital
Seville, Andalusia, 41013, Spain
Hospital Miguel Servet
Zaragoza, Aragon, 50009, Spain
Hospital Vall d'Hebron
Barcelona, Catalonia, 08035, Spain
Hospital Universitari de Bellvitge
Barcelona, Catalonia, 08907, Spain
Hospital Germans Trias i Pujol
Barcelona, Catalonia, 08916, Spain
Hospital Universitari Doctor Josep Trueta
Girona, Catalonia, 17007, Spain
Hospital General Universitario de Alicante
Alicante, Valencian, 03010, Spain
Hospital Universitario La Paz
Madrid, 28046, Spain
Hospital La Fe.com.Valencianna
Valencia, 46026, Spain
Hospital Gral Vigo, Galicia
Vigo, Spain
Buckinghamshire Healthcare NHS Trust - Wycombe Hospital
Buckingham, Buckinghamshire, HP11 2TT, United Kingdom
Norwich Hospital
Norwich, East of England, NR1-NR16, United Kingdom
Gloucestershire Royal Hospital
Gloucester, England, GL1 3NN, United Kingdom
Homerton Hospital
London, England, E9 6SR, United Kingdom
St Bartholomew's Hospital
London, England, EC1A 7BE, United Kingdom
Imperial College London Chelsea and Westminster Hospital NHS foundation
London, England, SW10 9NH, United Kingdom
James Cook University Hospital
Middlesbrough, England, TS4 3BW, United Kingdom
Northampton General Hospital
Northampton, England, NN1 5BD, United Kingdom
Royal Berkshire foundation NHS trust
Reading, England, RG1 5AN, United Kingdom
York Hospital
York, North Yorkshire, YO31 8H, United Kingdom
Horton General Hospital
Banbury, River Cherwell in Oxfordshire, OX16, United Kingdom
Royal Devon and Exeter NHS Foundation Trust
Exeter, West England, 01392, United Kingdom
Queen Elizabeth II
Birmingham, United Kingdom
Related Publications (4)
Kotecha D, Bunting KV, Mehta S, Sommer P, Sterlinski M, Rajappan K, Mont L, Guasch E, Boveda S, Boriani G, Sun Y, van Deutekom C, Gale CP, De Potter TJR, van Gelder IC; STEEER-AF investigators. Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial. Nat Med. 2025 Aug;31(8):2647-2654. doi: 10.1038/s41591-025-03751-2. Epub 2025 Jun 13.
PMID: 40514462DERIVEDSterlinski M, Bunting KV, Boriani G, Boveda S, Guasch E, Mont L, Rajappan K, Sommer P, Mehta S, Sun Y, Gale CP, van Deutekom C, Van Gelder IC, Kotecha D; STEEER-AF Trial Team. Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association. Europace. 2024 Jul 2;26(7):euae178. doi: 10.1093/europace/euae178.
PMID: 38940494DERIVEDSzymanski P, Weidinger F, Lordereau-Richard I, Himmelmann A, Arca M, Chaves J, Lee C, Jonker C, Kotecha D, O'Kelly J, Plueschke K, Rys A, Segec A, Wallentin L, Veltrop R, James S. Real world evidence: Perspectives from a European Society of Cardiology Cardiovascular Round Table with contribution from the European Medicines Agency. Eur Heart J Qual Care Clin Outcomes. 2023 Feb 28;9(2):109-118. doi: 10.1093/ehjqcco/qcad009.
PMID: 36746430DERIVEDBanerjee A, Pasea L, Chung SC, Direk K, Asselbergs FW, Grobbee DE, Kotecha D, Anker SD, Dyszynski T, Tyl B, Denaxas S, Lumbers RT, Hemingway H. A population-based study of 92 clinically recognized risk factors for heart failure: co-occurrence, prognosis and preventive potential. Eur J Heart Fail. 2022 Mar;24(3):466-480. doi: 10.1002/ejhf.2417. Epub 2022 Jan 26.
PMID: 34969173DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Hein Heidbuchel
Universiteit Antwerpen
- STUDY DIRECTOR
Dipak Kotecha
University of Birmingham
- STUDY DIRECTOR
Isabelle van Gelder
University Medical Center Groningen, The Netherlands
- PRINCIPAL INVESTIGATOR
Serge Boveda
Clinique Pasteur, France
- PRINCIPAL INVESTIGATOR
Philipp Sommer
Ruhr-Universität Bochum, Germany
- PRINCIPAL INVESTIGATOR
Giuseppe Boriani
University of Modena & Reggio Emilia
- PRINCIPAL INVESTIGATOR
Maciej Sterliński
National Institute of Cardiology, Warsaw, Poland
- PRINCIPAL INVESTIGATOR
Luis Mont
University of Barcelona, Spain
- PRINCIPAL INVESTIGATOR
Kim Rajappan
University of Oxford, UK
- PRINCIPAL INVESTIGATOR
Eduard Guasch
University of Barcelona, Spain
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 14, 2020
First Posted
May 20, 2020
Study Start
December 29, 2021
Primary Completion
January 10, 2024
Study Completion
December 30, 2025
Last Updated
June 20, 2024
Record last verified: 2024-06