NCT04390919

Brief Summary

To explore the prognostic indicators for patients with ADHF

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
362

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Aug 2011

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 2, 2011

Completed
3.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 16, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 16, 2015

Completed
5.2 years until next milestone

First Submitted

Initial submission to the registry

May 4, 2020

Completed
14 days until next milestone

First Posted

Study publicly available on registry

May 18, 2020

Completed
Last Updated

May 18, 2020

Status Verified

May 1, 2020

Enrollment Period

3.5 years

First QC Date

May 4, 2020

Last Update Submit

May 13, 2020

Conditions

Keywords

monocyte countheart failureacute decompensated heart failureall-cause death

Outcome Measures

Primary Outcomes (1)

  • all-cause death

    The primary end point was one-year all-cause death

    1 year

Secondary Outcomes (1)

  • HF-related rehospitalization

    1 year

Study Arms (2)

high group

high group: monocyte count≥0.445×10\*9 cells/L

Other: elevated monocyte count

low group

low group: monocyte count\<0.445×10\*9 cells/L;

Interventions

The monocyte count at admission was higher than 0.445×10\*9 cells/L

high group

Eligibility Criteria

Age18 Years - 94 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

ADHF patient diagnosed in the department of cardiovascular medicine in the first affiliated hospital of chongqing medical university

You may qualify if:

  • Patients with ADHF diagnosed according to ESC Guidelines for the diagnosis of acute heart failure 2008

You may not qualify if:

  • disorders of the hematopoietic system, history of cancer and/or previous treatment with chemotherapy, the infection caused by various pathogens, chronic inflammatory conditions, glucocorticoid therapy and/or histories of glucocorticoid use 3 months before the admission and acute myocardial infarction or coronary revascularization within the past 6 months. Also, patients who did not have a differential WBC count or who were lost to follow-up were excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
professor

Study Record Dates

First Submitted

May 4, 2020

First Posted

May 18, 2020

Study Start

August 2, 2011

Primary Completion

February 16, 2015

Study Completion

February 16, 2015

Last Updated

May 18, 2020

Record last verified: 2020-05