Trials Sponsors Conditions Drugs Pricing

Conditions

Hematologic Diseases Stem Cell Transplant Complications

Keywords

Allogeneic stem cell transplantationElderlyRetrospective surveyGITMOHematological disease

Outcome Measures

Primary Outcomes (4)

Overall Survival (OS)
is defined as the time from transplant to the date of death due to any cause or to the last date the patient was known to be alive (censored observation) or to the date of the data cut-off for final analysis
These outcome measures will be assessed at 5 years from allo-SCT.
Disease Free Survival (DFS)
DFS is defined as the probability of being alive free of disease at any point in time.
These outcome measures will be assessed at 5 years from transplant
Transplant Related Mortality (TRM)
TRM was defined as death due to any transplantation-related cause other than disease relapse
These outcome measures will be assessed at 5 years from transplant
Relapse risk (RR)
The relative risk (RR) or risk ratio is the ratio of the probability of an outcome in an exposed group to the probability of an outcome in an unexposed group.

Secondary Outcomes (2)

Acute Graft-versus-Host Disease
These outcome measures will be assessed at 100 days from transplant
Chronic Graft-versus-Host Disease
These outcome measures will be assessed at 5 years from transplant

Study Arms (1)

Elderly patients with hematological disease

older than 60 years who received hematopoietic stem cell transplantation (HSCT)

Eligibility Criteria

Age60 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodProbability Sample

Study Population

This study will enrol patients older than 60 years who received hematopoietic stem cell transplantation (HSCT) between 1st January 2000 and 31st December 2017.

You may qualify if:

Allogeneic transplantation from 2000 to 2017 (for patients submitted to more than one transplant, only the first transplant will be considered)

Sponsors & Collaborators

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Othercollaborator
Gruppo Italiano Trapianto di Midollo Osseo
Otherlead

Study Sites (29)

Azienda Ospedaliero-Universitaria Ospedali Riuniti

Ancona, Italy

Ospedale Mazzoni

Ascoli Piceno, Italy

Policlinico di Bari-Ematologia con trapianti

Bari, Italy

Ospedale San Orsola

Bologna, Italy

Ospedale Regionale Generale- Divisione Ematologia

Bolzano, Italy

ASST Spedali Civili

Brescia, Italy

CTMO PO "Businco" A.O. "G. Brotzu"

Cagliari, Italy

MeSH Terms

Conditions

Hematologic Diseases

Condition Hierarchy (Ancestors)

Hemic and Lymphatic Diseases

Study Officials

Michele Malagola, MD
Asst Degli Spedali Civili Di Brescia
PRINCIPAL INVESTIGATOR

Enrollment

1,996 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: RETROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

May 5, 2020

First Posted

May 13, 2020

Study Start

April 1, 2019

Actual (reported)

ALLO-SCT in Elderly Patients With Hematological Disease

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (4)

Secondary Outcomes (2)

Study Arms (1)

Elderly patients with hematological disease

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (29)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (4)

Secondary Outcomes (2)

Study Arms (1)

Elderly patients with hematological disease

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (29)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations