Bioequivalence Study of Lopinavir/Ritonavir 200/50 mg Film Tablet (World Medicine Ilac, Turkey) Under Fasting Conditions

NCT04386876 | Completed Phase 1 DMC

• 2 other identifiers: NOV2020/01911FARGE365
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 2

Brief Summary

A single dose of Reference product containing 200 mg lopinavir and 50 mg ritonavir fixed dose combination and a single dose of Test product containing 200 mg lopinavir and 50 mg ritonavir fixed dose combination or vice versa; administered with 240 mL of water at room temperature, in each period under fasting conditions.

Conditions

Bioequivalence

Keywords

COVID-19 drug treatment; Ritonavir; Lopinavir; Antiviral Agents; Kaletra; Novagenix; Farmagen

Outcome Measures

Primary Outcomes (2)

• Primary PK End Points

  AUC0-tlast of lopinavir and ritonavir

  12 weeks

• Primary PK End Points

  Cmax of lopinavir and ritonavir

  13 weeks

Study Arms (2)

Orvical-Kaletra-Orvical-Kaletra

EXPERIMENTAL

In first and third periods of the study, participants received Orvical 200 mg/50 mg Film Tablet manufactured by World Medicine-Turkey. In second and fourth periods, they received Kaletra 200 mg/50 mg Film CoatedTablet manufactured by AbbVie Deutschland GmbH \& Co.-Germany. All periods were performed under fasting state.

Drug: Lopinavir/Ritonavir 200 mg/50 mg Film Tablet; Drug: Lopinavir/Ritonavir 200 mg/50 mg Film Coated Tablet

Kaletra-Orvical-Kaletra-Orvical

EXPERIMENTAL

In first and third periods of the study, participants received Kaletra 200 mg/50 mg Film Coated Tablet manufactured by AbbVie Deutschland GmbH \& Co.-Germany. In second and fourth periods, they received Orvical 200 mg/50 mg Film Tablet manufactured by World Medicine-Turkey. All periods were performed under fasting state.

Drug: Lopinavir/Ritonavir 200 mg/50 mg Film Tablet; Drug: Lopinavir/Ritonavir 200 mg/50 mg Film Coated Tablet

Interventions

Lopinavir/Ritonavir 200 mg/50 mg Film Tablet DRUG

Lopinavir/Ritonavir film tablet containing 200 mg lopinavir and 50 mg ritonavir (World Medicine-Turkey).

Also known as: Orvical 200 mg/50 mg Film Tablet

Kaletra-Orvical-Kaletra-Orvical; Orvical-Kaletra-Orvical-Kaletra

Lopinavir/Ritonavir 200 mg/50 mg Film Coated Tablet DRUG

Lopinavir/Ritonavir film coated tablet containing 200 mg lopinavir and 50 mg ritonavir(AbbVie Deutschland GmbH \& Co.-Germany)

Also known as: Kaletra 200 mg/50 mg Film Coated Tablet

Kaletra-Orvical-Kaletra-Orvical; Orvical-Kaletra-Orvical-Kaletra

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy Caucasian male subjects aged between 20 and 40 years,
• Non smokers or smoking maximum 5 cigarettes a day, those who won't smoke or drink coffee during the study period,
• Negative Covid-19 Rapid Test results and two Negative Covid-19 PCR test results,
• Negative alcohol breath test results,
• Normal physical examination at screening visit,
• Having the Body Mass Index ranged between 18.5-30 kg/m2 (see Appendix I) which is in the desirable range according to the age,
• Ability to communicate adequately with the investigator himself or his representatives,
• Ability and agreement to comply with the study requirements,
• Normal blood pressure and heart rate measured under stabilised conditions at the screening visit after at least 5 minutes of rest under supine position: SBP within 100 to 140 mmHg, DBP within 60 to 90 mmHg and HR within 50 to 90 bpm,
• Normal/ acceptable 12-lead electrocardiographic results at least after 5 minutes of rest,
• Laboratory results within normal range or clinically non-significant (CBC, glucose, urea, uric acid, creatinine, estimated GFR (eGFR), total bilirubin, sodium, potassium, calcium, chloride, SGOT (AST), SGPT (ALT), GGT, alkaline phosphatase, total protein and urinalysis), drug addiction scanning in urine results in negative (amphetamine, barbiturate, benzodiazepine, cannabinoid, cocaine, opiate),
• Understanding of the study and agreement to give a written informed consent according to section 20.3.
• Volunteer's compliance with isolation rules defined at study protocol

You may not qualify if:

• Who have atopic constitution or asthma or known allergy for lopinavir and ritonavir or any other ingredients of the products.
• Any history or presence of clinical relevance of cardiovascular (myocardial infarction/ ischaemia and/or QT prolongation etc.), neurological, musculoskeletal, haematological, hepatic, gastrointestinal, renal, pulmonary, endocrinological, metabolism or psychiatric disease, any type of porphyria.
• Baseline ECG should be performed at screening. Exclude subjects having a QTc \> 440 ms
• Symptomatic or asymptomatic orthostatic hypotension at screening or before the first drug administration defined by a decrease of SBP more than 20 mmHg or DBD more than 10 mmHg occurs between sitting/supine to standing position subject will be excluded (if it deemed necessary by the investigator),
• Presence or history of malabsorption or any gastrointestinal surgery except appendectomy or except herniotomy.
• Subjects who have given more than 400 mL blood within the last two months before the first drug administration and subjects who have participated to any drug research within the last two months before the first drug administration.
• Subjects suspected to have a high probability of non-compliance to the study procedure and/or completion of the study according to the investigator's judgement.
• Subjects who used any of prescribed systemic or topical medication (including OTC medication) within 2 weeks (or six elimination half lives of this medication, whichever is longer) before the initiation of the study (except single doses of analgesics which have no drug interaction with study product).
• Use of any vitamins or herbal products within 7 days prior to the initial dose of the study medication.
• Subjects who have any chronic disease which might interfere with absorption, distribution, metabolism or excretion of the drug.
• Subjects who regular consumed of beverages or food containing methylxanthines (e.g. coffee, tea, cola, caffeine, chocolate, sodas,) equivalent to more than 500 mg methylxanthines per day.
• Subjects who has taken any grapefruit or grapefruit juice during 7 days prior to drug administration, during the study.
• History of allergic response to heparin.
• History of drug abuse.
• History of alcohol abuse and/or regular use of more than 2 units of alcohol per day or 10 units per week and/or positive alcohol breath test results (Note: one unit of alcohol equals 250 mL beer, 125 mL wine or 25 mL spirits).

Sponsors & Collaborators

• World Medicine ILAC SAN. ve TIC. A.S.: lead
• Novagenix Bioanalytical Drug R&D Center: collaborator
• Farmagen Ar-Ge Biyot. Ltd. Sti: collaborator

Study Sites (2)

Novagenix Drug R&D Center

Akyurt, Ankara, 06970, Turkey (Türkiye)

Location

Farmagen Ar-Ge Biyot. Ltd. Sti.

Şahinbey, Gaziantep, 27000, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Lopinavir; Ritonavir; Motion Pictures; lopinavir-ritonavir drug combination

Intervention Hierarchy (Ancestors)

Pyrimidinones; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Thiazoles; Sulfur Compounds; Organic Chemicals; Azoles; Audiovisual Aids; Educational Technology; Technology; Technology, Industry, and Agriculture

Study Officials

• Muradiye Nacak, MD,PhD

  Farmagen Ar-Ge Biyot. Ltd. Sti

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Single Oral Dose,Two Treatment,Four-period,Full-replicated,Cross-over

Study Record Dates

• First Submitted: May 5, 2020
• First Posted: May 13, 2020
• Study Start: April 30, 2020
• Primary Completion: May 22, 2020
• Study Completion: June 11, 2020
• Last Updated: December 31, 2020

Record last verified: 2020-11

Locations

TU (2)