ASPIrin in Reducing Events in Dialysis ( ASPIRED )
1 other identifier
interventional
9,082
1 country
127
Brief Summary
People with kidney failure requiring dialysis have a much higher risk of developing cardiovascular (CV) disease compared with the general population. A cardiac cause accounts for 58% of all deaths in patients with end stage kidney disease (ESKD). At the same time, this population has increased risks of clotting as well as bleeding episodes. While aspirin is known to reduce cardiovascular complications in the general population, evidence to support the use of aspirin in people with ESKD receiving dialysis therapy is currently lacking. The ASPIrin to Reduce Event in Dialysis (ASPIRED) trial will test whether aspirin use in dialysis patients safely improves outcomes compared with no aspirin use.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
Started Jul 2020
Longer than P75 for phase_4
127 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 23, 2020
CompletedFirst Posted
Study publicly available on registry
May 8, 2020
CompletedStudy Start
First participant enrolled
July 30, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2026
ExpectedSeptember 14, 2026
September 1, 2026
6.2 years
April 23, 2020
September 10, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of Participants with composite of major cardiovascular events (3-point MACE)
A composite of cardiovascular death, myocardial infarction, or ischemic stroke.
From trial initiation to any event first occurrence, up to 5 years.
Secondary Outcomes (11)
Number of Participants with composite of major cardiovascular events plus all-cause death
From trial initiation to any event first occurrence, up to 5 years.
Number of Participants with composite of major cardiovascular events, hospitalised unstable angina (UA) and hospitalised transient ischaemic attack (TIA)
From trial initiation to any event first occurrence, up to 5 years.
Number of Participants with cardiovascular death
From trial initiation to any event first occurrence, up to 5 years.
Number of Participants with Myocardial infarction
From trial initiation to any event first occurrence, up to 5 years.
Number of Participants with ischemic stroke
From trial initiation to any event first occurrence, up to 5 years.
- +6 more secondary outcomes
Other Outcomes (1)
Major bleeding
From trial initiation to any event first occurrence, up to 5 years.
Study Arms (2)
Aspirin
ACTIVE COMPARATORAspirin tablet 100mg daily
Matching Placebo
PLACEBO COMPARATORPlacebo tablet 1 pill daily
Interventions
Eligibility Criteria
You may qualify if:
- Incident or prevalent adults (≥18 years old) dialysis patients are included in the Dialysis Registry.
- Commenced on dialysis with the expectation of ongoing maintenance dialysis requirement.
- Willing and able to provide informed consent for this study.
You may not qualify if:
- Requirement for any form of antiplatelet agent (aspirin, glycoprotein IIb/IIIa inhibitors etc), or oral anticoagulation (warfarin, NOACs), in the view of the treating physician.
- Contraindication to aspirin, in the view of the treating physician.
- Dialysis requirement due to acute kidney injure with expectation of kidney function recovery.
- History of haemorrhagic stroke or intracranial bleed within 12 months of screening.
- Coagulopathy from any cause.
- Unable to provide informed consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Guangdong Provincial People's Hospitallead
- The George Institutecollaborator
Study Sites (127)
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
Shanghang County Hospital
Longyan, Fujian, 364299, China
The First Hospital of Lanzhou University
Lanzhou, Gansu, China
Dongguan Donghua Hospital
Dongguan, Guangdong, 523413, China
Dongguan Hospital of Integrative Traditional Chinese and Western Medicine
Dongguan, Guangdong, 523819, China
Dongguan Houjie Hospital
Dongguan, Guangdong, 523955, China
Dongguan Eighth People's Hospital
Dongguan, Guangdong, China
Dongguan Marina Bay Center Hospital
Dongguan, Guangdong, China
Dongguan People's Hospital
Dongguan, Guangdong, China
Foshan Gaoming District People's Hospital
Foshan, Guangdong, 528000, China
The Second People Hospital of Foshan Nanhai
Foshan, Guangdong, 528251, China
Foshan Nanhai District People's Hospital
Foshan, Guangdong, China
Foshan No.1 people's hospital
Foshan, Guangdong, China
Foshan Sanshui People's Hospital
Foshan, Guangdong, China
Foshan Second People's Hospital
Foshan, Guangdong, China
Guangdong Provincial Hospital of Integrative Medicine
Foshan, Guangdong, China
The Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, 225200, China
The First Affiliated Hospital of Guangdong Medical University
Guangzhou, Guangdong, 510120, China
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, 510235, China
Guangzhou Redcross Hospital
Guangzhou, Guangdong, 510240, China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, 510280, China
Guangdong Provincial Hospital of Traditional Chinese Medicine Fangcun Branch (Guangzhou Charity Hospital)
Guangzhou, Guangdong, 510370, China
The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510630, China
The Fifth Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, 510900, China
Guangdong Agricultural Reclamation Central Hospital
Guangzhou, Guangdong, China
Guangdong Cliffod Hospital
Guangzhou, Guangdong, China
Guangdong Provincial Peoples Hospital
Guangzhou, Guangdong, China
Guangzhou First People's Hospital
Guangzhou, Guangdong, China
Hua Du District People's Hospital of Guangzhou
Guangzhou, Guangdong, China
Panyu District people's hospital of Guangzhou
Guangzhou, Guangdong, China
The Fifth Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
The Sixth Affiliated Hospital of Sun yat-sen University
Guangzhou, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Sun Yat-sen University
Guanzhou, Guangdong, China
Heyuan People's Hospital
Heyuan, Guangdong, China
Huizhou First People Hospital
Huizhou, Guangdong, 516001, China
Huizhou Central People's Hospital
Huizhou, Guangdong, China
The People's Hospital of Jiangmen
Jiangmen, Guangdong, 529000, China
Jiangmen Center hospital
Jiangmen, Guangdong, China
Jieyang People's Hospital
Jieyang, Guangdong, China
Kaiping Center Hospital
Kaiping, Guangdong, China
Lianjiang People's Hospital
Lianjiang, Guangdong, China
Lianping County People's Hospital
Lianping, Guangdong, 517100, China
The Fourth Affiliated Hospital of Guangzhou Medical University
Licheng, Guangdong, China
Maoming Hospital of Traditional Chinese Medicine
Maoming, Guangdong, China
Maoming People's Hospital
Maoming, Guangdong, China
Meizhou People's Hospital
Meizhou, Guangdong, 514011, China
The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital
Meizhou, Guangdong, 514799, China
Puning People's Hospital
Puning, Guangdong, China
Qingyuan People's Hospital
Qingyuan, Guangdong, 511518, China
Fogang People Hospital
Qingyuan, Guangdong, 511600, China
Qingyuan Hospital of Traditional Chinese Medicine
Qingyuan, Guangdong, China
The first Affiliated Hospital of Shantou Medical University
Shantou, Guangdong, 515041, China
Shantou Chaonan Minsheng Hospital
Shantou, Guangdong, 515144, China
Shanwei People's Hospital
Shanwei, Guangdong, China
Shenshan Medical Center, Memorial Hospital of Sun Yat-sen University
Shanwei, Guangdong, China
Wengyuan People Hospital
Shaoguan, Guangdong, 512600, China
Shaoguan First People's Hospital
Shaoguan, Guangdong, China
The First People's Hospital of Shaoguan
Shaoguan, Guangdong, China
Yuebei People's Hospital
Shaoguan, Guangdong, China
The Seventh Affiliated Hospital of Sun Yat-sen
Shenzhen, Guangdong, 510275, China
Peking University Shenzhen Hospital
Shenzhen, Guangdong, 518036, China
Shenzhen Baoan People's Hospital
Shenzhen, Guangdong, China
Shenzhen Hospital of Southern Medical University
Shenzhen, Guangdong, China
Shenzhen Longhua District People's Hospital
Shenzhen, Guangdong, China
Shenzhen No.2 people's hospital
Shenzhen, Guangdong, China
The Eighth Affiliated Hospital of Sun Yat-sen University (Futian, Shenzhen)
Shenzhen, Guangdong, China
ShunDe Hospital Guangzhou University of Chinese Medicine
Shunde, Guangdong, China
The Eighth Affiliated Hospital of Southern Medical University, The First People's Hospital of Shunde
Shunde, Guangdong, China
Nanxiong People Hospital
Xiongzhou, Guangdong, 512499, China
People's Hospital of Yangdong District Yangjiang City
Yangjiang, Guangdong, 529900, China
Yangjiang Hospital of Traditional Chinese Medicine
Yangjiang, Guangdong, China
Yangjiang People's Hospital
Yangjiang, Guangdong, China
People Hospital of Yingde City Guangdong Province
Yingcheng, Guangdong, China
Yunfu People's Hospital
Yunfu, Guangdong, China
The Affiliated Hospital of Guangdong Medical University
Zhanjiang, Guangdong, 524000, China
Central People's Hospital of Zhanjiang
Zhanjiang, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University Zhaoqing Hospital
Zhaoqing, Guangdong, 526070, China
Zhaoqing first people's hospital
Zhaoqing, Guangdong, China
Zhongshan City People's Hospital
Zhongshan, Guangdong, China
Zhongshan Xiaolan People's Hospital
Zhongshan, Guangdong, China
Jinwan Center Hospital of Zhuhai
Zhuhai, Guangdong, China
The fifth affiliated hospital of sun yat-sen university
Zhuhai, Guangdong, China
Zhuhai People's Hospital
Zhuhai, Guangdong, China
Shantou Central Hospital
Shantou, Guanggong, 515100, China
The Affiliated Hospital of Youjiang Ethnic Medicine College
Baise City, Guangxi, China
The first affiliated hospital of Guangxi Medical University
Nanning, Guangxi, China
Anshun Xixiu District People's Hispital
Anshun, Guizhou, 561000, China
China Guihang 302 Hospital
Anshun, Guizhou, 561000, China
Anshun People Hospital
Anshun, Guizhou, 561099, China
The First Affiliated Hospital of Hainan Medical University
Haikou, Hainan, 570105, China
Hainan Provincial People's Hospital
Haikou, Hainan, China
Xinyang Central Hospital
Xinyang, Henan, China
Huangshi Central Hospital
Huangshi, Hubei, 435000, China
Jingmen Central Hospital
Jingmen, Hubei, 448001, China
Jingzhou Central Hospital
Jingzhou, Hubei, 434020, China
Wuhan Puren Hospital
Wuhan, Hubei, 430012, China
The First People's Hospital of Jiangxia District, Wuhan City
Wuhan, Hubei, 430200, China
The Central Hospital of Wuhan
Wuhan, Hubei, China
The Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China
Tongji Hospital, Tongji Medical College of Huazhong Science and Technology University
Wuhan, Hubei, China
Wuhan No.1 People's Hospital
Wuhan, Hubei, China
Xiangyang Central Hospital
Xiangyang, Hubei, 441021, China
Hunan Provincial People's Hospital
Changsha, Hunan, China
The third Xiangya Hospital of Central South University
Changsha, Hunan, China
Xiangya Hospital Central South University
Changsha, Hunan, China
Nantong Haimen People's Hospital
Nantong, Jiangsu, 226199, China
Xuzhou Mining Group General Hospital
Xuzhou, Jiangsu, 221006, China
Subei People's Hospital
Yangzhou, Jiangsu, 225001, China
Ganzhou Municiple Hospital
Ganzhou, Jiangxi, 341000, China
Ganzhou People's Hospital
Ganzhou, Jiangxi, China
Jiujiang No.1people's Hospital
Jiujiang, Jiangxi, China
Jiangxi Province Peple's Hospital
Nanchang, Jiangxi, China
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital)
Xi’an, Shanxi, 710004, China
Sichuan Province People's Hospital
Chengdu, Sichuan, China
Jiashi County People's Hospital
Kashgar, Xinjiang, 844399, China
Shache County People's Hospital
Kashgar, Xinjiang, 844700, China
The First People's Hospital of Kashi Prefecture
Kashgar, Xinjiang, China
The Second People's Hospital of Kashi Prefecture
Kashgar, Xinjiang, China
The First Affiliated Hospital of Shihezi University Medical College
Shihezi, Xinjiang, China
Fengqing People's Hospital of Yunnan Province
Lincang, Yunnan, China
The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang, China
Lishui City Center Hospital
Lishui, Zhejiang, 323020, China
Zhoushan Hospital
Zhoushan, Zhejiang, 316100, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Xueqing Yu
Guangdong Provincial People's Hospital
- STUDY CHAIR
Vlado Perkovic
The University of New South Wales Sydney
- STUDY DIRECTOR
Muh Geot Wong
The George Institute
- STUDY DIRECTOR
Wei Chen
First Affiliated Hospital, Sun Yat-Sen University
- STUDY DIRECTOR
Li Fan
Guangdong Provincial People's Hospital
- STUDY DIRECTOR
Zhiming Ye
Guangdong Provincial People's Hospital
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 23, 2020
First Posted
May 8, 2020
Study Start
July 30, 2020
Primary Completion
September 30, 2026
Study Completion (Estimated)
December 31, 2026
Last Updated
September 14, 2026
Record last verified: 2026-09
Data Sharing
- IPD Sharing
- Will share
Deidentified study data that supports the results will be shared following publication. Any sub-study analysis and publication will have to be reviewed and approved by the Trial Steering Committee, local Ethics and Regulatory requirements.