Using Bedside Ultrasound to Screen for Sarcopenia in Older Adults

NCT04370912 | Completed

• 1 other identifier: H20-01355
• Study Type: observational
• Target: 152
• Locations: 1 country
• Sites: 1

Brief Summary

The loss of both muscle mass and quality with increasing age is called 'sarcopenia' and is a risk factor for falls, fractures and increased mortality. Sarcopenia is diagnosed with Dual-energy X-ray absorptiometry (DXA) scanning (according to current criteria), but in Canada DXA scans are not approved to screen for this condition. One potential solution is Point of Care Ultrasound (PoCUS), since recent advances have made bedside ultrasound technology readily available as a rapid bedside screening tool.

Conditions

Sarcopenia

Outcome Measures

Primary Outcomes (4)

• US measurement for Sarcopenia

  o establish PoCUS measures (muscle thickness, MT; echointensity, EI) as a new screening test for sarcopenia

  through study completion, an average of 1 year

• Weight in kg

  weight and height will be combined to report BMI in kg/m\^2

  through study completion, an average of 1 year

• Height in cm

  weight and height will be combined to report BMI in kg/m\^2

  through study completion, an average of 1 year

• Handgrip strength in kg

  Handgrip strength cutoffs for sarcopenia for men and women

  through study completion, an average of 1 year

Interventions

Bed side Ultrasound DIAGNOSTIC_TEST

Handgrip strength will be measured using a digital grip strength dynamometer (Sammons Preston, Nottinghamshire, UK). This measurement is carried out three times using the subject's dominant hand, and then averaged

Also known as: Grip strength, Appendicular Skeletal Mass assessment

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects will be recruited from Vancouver Coastal Health Authority has 5 outpatient geriatric medicine clinics that continuously for 5 days per week and see 4000 new patients per year.

You may qualify if:

• each subject must be 65 years of age or greater

You may not qualify if:

• hemodialysis patients will be excluded, due to excessive fluid shifts with dialysis
• patients using chronic oral corticosteroids will be excluded, due to potential muscle atrophy
• hemiparesis due to a stroke or paresis of the lower limbs will be excluded
• subjects with pitting edema on physical exam (due to liver, renal or heart failure) or patients that are severely dehydrated will be excluded
• patients with myositis, systemic connective tissue disorders, systemic atrophies affecting the central nervous system (CNS) and CNS demyelinating diseases will be excluded

Sponsors & Collaborators

• University of British Columbia: lead
• Canadian Institutes of Health Research (CIHR): collaborator

Study Sites (1)

Vancouver Coastal Health Research Institute, VGH Research Pavilion Room 186

Vancouver, British Columbia, V5Z 1M9, Canada

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Hand Strength

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Muscle Strength; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Kenneth Madden, MD

  UBC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Allan M. McGavin Chair in Geriatric Medicine Division Head, Vancouver General Hospital Division of Geriatric Medicine

Study Record Dates

• First Submitted: April 27, 2020
• First Posted: May 1, 2020
• Study Start: September 1, 2021
• Primary Completion: December 31, 2021
• Study Completion: April 1, 2022
• Last Updated: November 2, 2022

Record last verified: 2022-10

Locations

CA (1)