Interstitial Lung Diseases Cohort Study in China

NCT04370158 | Unknown

• 1 other identifier: ChinaJapanFH003
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

In this project, the clinical diagnosis of interstitial lung diseases was carried out for the population with suspected interstitial lung diseases selected from the community cohort, and the confirmed patients were included into the existing clinical cohort of interstitial lung diseases, forming an interstitial lung diseases special disease cohort consisting of 3,000 patients and corresponding matched control groups. According to characteristics of interstitial lung disease and the needs of National Key R\&D Program of China, this study will formulate unified clinical follow-up strategy to do long-term standardized clinical follow-up in patients with interstitial lung disease. The detailed information for clinical diagnosis and treatment as well as biological samples were collected to identify disease phenotype and build the database and biological sample library for interstitial lung disease cohort study. This study aims to provide evidence for molecular classification, screening and validation of biomarkers as well as precise diagnosis and prevention in patients with interstitial lung disease.

Conditions

Interstitial Lung Diseases

Outcome Measures

Primary Outcomes (1)

• Database and biological sample library for Chinese patients with interstitial lung disease

  Data analyses will be mainly descriptive.

  up to 4 years

Interventions

disease history OTHER

Clinical progression and prognosis of patients with interstitial lung diseases

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients from the hospitals involved in this study

You may qualify if:

• Physician diagnosed IPF during the last 3 months based upon ATS/ERS/JRS/ALAT guidelines 2011
• Agree to sign the informed consent

You may not qualify if:

• Lung transplantation expected within the next 6 months

Sponsors & Collaborators

• China-Japan Friendship Hospital: lead
• The First Affiliated Hospital of Guangzhou Medical University: collaborator
• Xiangya Hospital of Central South University: collaborator
• First Hospital of China Medical University: collaborator
• The Fourth Affiliated Hospital of China Medical University: collaborator
• Peking Union Medical College Hospital: collaborator

Study Sites (1)

Huaping Dai

Beijing, Beijing Municipality, 100029, China

RECRUITING

Related Publications (1)

• Wang H, Liu A, Ni Y, Wang J, Du J, Xi L, Qiang Y, Xie B, Ren Y, Wang S, Geng J, Deng Y, Huang S, Zhang R, Liu M, Dai H; China Interstitial Lung Disease Collaboration Network. Developing and Validation of a Multimodal-Based Machine Learning Model for Diagnosis of Usual Interstitial Pneumonia: A Prospective Multicenter Study. Chest. 2025 Sep 16:S0012-3692(25)05248-1. doi: 10.1016/j.chest.2025.08.034. Online ahead of print.

  PMID: 40967367 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood, BALF, lung tissue, fibroblast

MeSH Terms

Conditions

Lung Diseases, Interstitial

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 4 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Deputy Director of Center for Respiratory Diseases

Study Record Dates

• First Submitted: April 29, 2020
• First Posted: April 30, 2020
• Study Start: July 1, 2016
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: April 30, 2020

Record last verified: 2020-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)