Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series
1 other identifier
interventional
63
0 countries
N/A
Brief Summary
The authors conducted a case series to determine the outcomes of treatment of root surface caries lesions when the teeth were treated topically with 38% silver diamine fluoride.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jan 2017
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 3, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 21, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
November 21, 2019
CompletedFirst Submitted
Initial submission to the registry
April 23, 2020
CompletedFirst Posted
Study publicly available on registry
April 30, 2020
CompletedApril 30, 2020
April 1, 2020
2.9 years
April 23, 2020
April 29, 2020
Conditions
Outcome Measures
Primary Outcomes (5)
Dental caries lesion activity 1
Nyvad score based on visual/tactile examination
6-12 months
Dental caries lesion activity 2
Nyvad score based on visual/tactile examination
<6 months
Dental caries lesion activity 3
Nyvad score based on visual/tactile examination
12-18 months
Dental caries lesion activity 4
Nyvad score based on visual/tactile examination
18-24 months
Dental caries lesion activity 5
Nyvad score based on visual/tactile examination
24-30 months
Secondary Outcomes (5)
Caries lesion fluorescence 1
<6 months
Caries lesion fluorescence 2
6-12 months
Caries lesion fluorescence 3
12-18 months
Caries lesion fluorescence 4
18-24 months
Caries lesion fluorescence 5
24-30 months
Study Arms (1)
Silver Diamine Fluoride
EXPERIMENTALTopical application of one drop of silver diamine fluoride 38% to active untreated roof surface caries, lesions at the furcation, or lesions at crown margins. Application was repeated once each six months.
Interventions
Dental caries arrest medication
Eligibility Criteria
You may qualify if:
- At least 1 active root surface caries lesion by Nyvad criteria
You may not qualify if:
- None
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Nyvad B, Machiulskiene V, Baelum V. Reliability of a new caries diagnostic system differentiating between active and inactive caries lesions. Caries Res. 1999 Jul-Aug;33(4):252-60. doi: 10.1159/000016526.
PMID: 10343087BACKGROUNDMitchell C, Gross AJ, Milgrom P, Mancl L, Prince DB. Silver diamine fluoride treatment of active root caries lesions in older adults: A case series. J Dent. 2021 Feb;105:103561. doi: 10.1016/j.jdent.2020.103561. Epub 2020 Dec 24.
PMID: 33347946DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
David Prince, DDS
Roseman Health Sciences University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
April 23, 2020
First Posted
April 30, 2020
Study Start
January 3, 2017
Primary Completion
November 21, 2019
Study Completion
November 21, 2019
Last Updated
April 30, 2020
Record last verified: 2020-04