NCT04364295

Brief Summary

A global, prospective, non-randomized, multicenter, observational, post-market, medical record review registry evaluating real-world evidence for SeaSpine products.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,285

participants targeted

Target at P75+ for all trials

Timeline
27mo left

Started Mar 2020

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress73%
Mar 2020Aug 2028

Study Start

First participant enrolled

March 20, 2020

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

April 23, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 28, 2020

Completed
7.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2028

Expected
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2028

Last Updated

April 4, 2023

Status Verified

March 1, 2023

Enrollment Period

7.9 years

First QC Date

April 23, 2020

Last Update Submit

March 30, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Evaluation of product failure

    Product failure is defined as product fracture, loosening, gross migration and/or dissociation.

    12 months post-operative

Secondary Outcomes (1)

  • Incidence of product-related Serious Adverse Events (SAEs) related to the spine, fusion or bone healing, and intraoperative and postoperative unanticipated adverse device effects

    Intra-operative to 24 months

Study Arms (1)

Implanted with SeaSpine spinal or orthobiologics product

Standard of Care Registry- Patients must have been implanted with at least one SeaSpine product

Device: Spinal Surgery with SeaSpine product

Interventions

Implanted with SeaSpine spinal or orthobiologic product

Implanted with SeaSpine spinal or orthobiologics product

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Approximately 2285 patients who were previously implanted with SeaSpine products

You may qualify if:

  • Have been treated with at least one SeaSpine product.
  • Have obtained radiographic imaging, as part of the standard of care, at the following time points: preoperative and postoperative.
  • Have obtained at least one preoperative patient-reported outcome measure, as part of the standard of care.
  • Patient is planned, per standard of care, to be assessed with radiographic imaging and consistent patient-reported outcome measure(s) from preoperative through at least two scheduled follow-up visits.

You may not qualify if:

  • Was not implanted with at least one SeaSpine product during operation
  • Any other condition that the Investigator determines is unacceptable for enrollment into this registry

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Spine Colorado

Durango, Colorado, 81301, United States

Location

OrthoNeuro

New Albany, Ohio, 43054, United States

Location

MeSH Terms

Conditions

Spinal Diseases

Condition Hierarchy (Ancestors)

Bone DiseasesMusculoskeletal Diseases

Study Officials

  • Frank Vizesi, PhD

    SeaSpine Orthopedics Corporation

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
24 Months
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 23, 2020

First Posted

April 28, 2020

Study Start

March 20, 2020

Primary Completion (Estimated)

February 1, 2028

Study Completion (Estimated)

August 1, 2028

Last Updated

April 4, 2023

Record last verified: 2023-03

Data Sharing

IPD Sharing
Will not share

Locations