Improving Working Memory in Older Adults
1 other identifier
interventional
964
1 country
1
Brief Summary
The research program will evaluate the theoretical claim that age-related memory and cognitive decline in humans result from the inefficient orchestration of rhythmic activity within large-scale cortical networks. The results will contribute to the basic science groundwork for developing future non-pharmacological interventions aimed at boosting memory and cognition in aging and clinical populations.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2019
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2019
CompletedFirst Submitted
Initial submission to the registry
April 21, 2020
CompletedFirst Posted
Study publicly available on registry
April 27, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2026
CompletedJuly 23, 2026
July 1, 2026
6.7 years
April 21, 2020
July 22, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Memory performance success (sham stimulation condition)
The accuracy of task performance (in percentage correct units) in the delayed-match-to-sample working memory paradigm
During sham intervention
Memory performance success (active stimulation condition)
The accuracy of task performance (in percentage correct unit) in the delayed-match-to-sample working memory paradigm
During active intervention
Memory performance speed (sham stimulation condition)
The reaction time of task performance (in millisecond units) in the delayed-match-to-sample working memory paradigm
During sham intervention
Memory performance speed (active stimulation condition)
The reaction time of task performance (in millisecond units) in the delayed-match-to-sample working memory paradigm
During active intervention
Study Arms (2)
active stimulation
EXPERIMENTALsham stimulation
SHAM COMPARATORInterventions
Low-intensity and safe, noninvasive application of electrical current to the human scalp with the goal of gradually modulating levels of neuronal excitability.
Eligibility Criteria
You may qualify if:
- For Experiment 1, 18-30 years
- For Experiment 2, 60-80 years
- Normal or corrected-to-normal vision
- Has color vision.
You may not qualify if:
- Metal implants in the head
- Implanted electronic devices
- A history of neurological problems or head injury
- Skin sensitivity
- Claustrophobia
- Dementia \[Mini Mental State Examination (MMSE) score of 23 or lower; Montreal Cognitive Assessment score of \<26)
- Depression \[Beck Depression Inventory II score of 14 or higher; Geriatric Depression Scale score of 10 or higher\]
- Taking any psychoactive medication
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
111 Cummington Mall Room 264
Boston, Massachusetts, 02215, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Robert MG Reinhart, PhD
Boston University Charles River Campus
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
April 21, 2020
First Posted
April 27, 2020
Study Start
September 1, 2019
Primary Completion
April 30, 2026
Study Completion
April 30, 2026
Last Updated
July 23, 2026
Record last verified: 2026-07
Data Sharing
- IPD Sharing
- Will not share