NCT04362696

Brief Summary

The research program will evaluate the theoretical claim that age-related memory and cognitive decline in humans result from the inefficient orchestration of rhythmic activity within large-scale cortical networks. The results will contribute to the basic science groundwork for developing future non-pharmacological interventions aimed at boosting memory and cognition in aging and clinical populations.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
964

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2019

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

April 21, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

April 27, 2020

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2025

Completed
Last Updated

August 3, 2025

Status Verified

July 1, 2025

Enrollment Period

5.7 years

First QC Date

April 21, 2020

Last Update Submit

July 31, 2025

Conditions

Large-scale Physiological Foundations of Memory Decline in Aging Humans

Outcome Measures

Primary Outcomes (4)

  • Memory performance success (sham stimulation condition)

    The accuracy of task performance (in percentage correct units) in the delayed-match-to-sample working memory paradigm

    During sham intervention

  • Memory performance success (active stimulation condition)

    The accuracy of task performance (in percentage correct unit) in the delayed-match-to-sample working memory paradigm

    During active intervention

  • Memory performance speed (sham stimulation condition)

    The reaction time of task performance (in millisecond units) in the delayed-match-to-sample working memory paradigm

    During sham intervention

  • Memory performance speed (active stimulation condition)

    The reaction time of task performance (in millisecond units) in the delayed-match-to-sample working memory paradigm

    During active intervention

Study Arms (2)

active stimulation

EXPERIMENTAL
Device: High definition transcranial electrical current stimulation

sham stimulation

SHAM COMPARATOR
Device: High definition transcranial electrical current stimulation

Interventions

High definition transcranial electrical current stimulationDEVICE

Low-intensity and safe, noninvasive application of electrical current to the human scalp with the goal of gradually modulating levels of neuronal excitability.

active stimulationsham stimulation

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

677 Beacon St. Room 308

Boston, Massachusetts, 02215, United States

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

April 21, 2020

First Posted

April 27, 2020

Study Start

September 1, 2019

Primary Completion

April 30, 2025

Study Completion

April 30, 2025

Last Updated

August 3, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations

US(1)