18F-FDG PET Imaging Analysis of Antiepileptic Drug Response in BECTS
1 other identifier
observational
55
1 country
1
Brief Summary
This original article is a novel investigation on the metabolic characteristics of different patterns of antiepileptic drug (AED) responses in benign epilepsy with centrotemporal spikes (BECTS) patients using 18F-FDG PET imaging. In this study, we demonstrated remitting-relapsing group showed more widespread hypo-metabolism regions than AED responders. Results indicated that metabolic differences had the ability to distinguish the remitting-relapsing patients from AED responders. 18F-FDG PET could be used as a marker to infer the current seizure activity of BECTS. We think that the established hybrid model based on PET and clinical features may be a critical reference for better personalized medication in patients with BECTS.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 30, 2020
CompletedFirst Submitted
Initial submission to the registry
April 20, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
April 20, 2020
CompletedFirst Posted
Study publicly available on registry
April 22, 2020
CompletedApril 22, 2020
April 1, 2020
10 months
April 20, 2020
April 20, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The 'area under curve' (AUC ) of our model in classification performance
To evaluate the performance of our model, the investigators calculated the AUC of three different logistic regression models based on clinical features, 18F-FDG PET images and a hybrid of both.
Through study completion, about 6 months
Study Arms (2)
Experimental Group
The experimental group received 18F-FDG PET examination
Control Group
The control group received 18F-FDG PET examination
Eligibility Criteria
Pediatric patients with benign epilepsy with centrotemporal spikes
You may qualify if:
- clinical diagnosis of BECTS; 2. aging between 6 and 18 years ; 3.taking MRI and EEG examination; 4. taking AEDs as prescribed; 5. continuous 12-month clinical follow-up after 18F-FDG PET examination; 6.the last seizure occurring earlier than 24 h before 18F-FDG PET study
You may not qualify if:
- any history of neurological disorders, such as head trauma, tumor or infarct
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, 310009, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 20, 2020
First Posted
April 22, 2020
Study Start
June 1, 2019
Primary Completion
March 30, 2020
Study Completion
April 20, 2020
Last Updated
April 22, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share