Factors Predicting Urethral Stricture Recurrence After Dorsal Onlay Augmented, Buccal Mucosal Graft Urethroplasty

NCT04357080 | Completed

• 1 other identifier: Uro_Azhar_4_020
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

In this observational study, the investigators will evaluate potential risk factors associated with urethral stricture recurrence after augmentation anterior urethroplasty using dorsal onlay buccal mucosal Graft during the past 10 years. Patients' medical files will be reviewed for data relevant to demographics, clinical and operative characteristics. data will be analyzed using the appropriate statistical tests and the independent predictors of urethroplasty outcome will be identified.

Conditions

Urethral Stricture

Outcome Measures

Primary Outcomes (2)

• urethral restricture rate

  The presence of radiologic and endoscopic features of urethral stricture recurrence, as diagnosed by urethrography and cystoscopy during follow-up.

  At any time from date of surgery until the last follow-up visit (up to 10 years)

• Time to urethral restricture.

  will be calculated from the date of surgery until the date restricture diagnosis

  The time from urethroplasty surgery until the time of urethral restricure diagnosis (at any follow-up time point, up to 10 years), as recorded in patients medical files).

Study Arms (2)

Case

Patients with urethral stricture recurrence

Procedure: Urethroplasty

Control

Patients with normal, patent urethra

Procedure: Urethroplasty

Interventions

Urethroplasty PROCEDURE

Augmentation Anterior Urethroplasty Using Dorsal Onlay Buccal Mucosal Graft

Case; Control

Eligibility Criteria

• Gender Eligibility Details: male of any age
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients who underwent augmented anterior urethroplasty with buccal mucosal graft at Al-Azhar University Hospital in the past 10 years

You may qualify if:

• patients who will be 2 years or more out of surgery

You may not qualify if:

• patients with incomplete medical records or follow-up informations

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Urology Department, Al-Azhar University Hospital

Cairo, 11633, Egypt

Location

MeSH Terms

Conditions

Urethral Stricture

Condition Hierarchy (Ancestors)

Urethral Obstruction; Urethral Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Urology and Andrology

Study Record Dates

• First Submitted: April 19, 2020
• First Posted: April 22, 2020
• Study Start: July 15, 2020
• Primary Completion: August 15, 2020
• Study Completion: August 29, 2020
• Last Updated: January 13, 2021

Record last verified: 2020-04

Locations

EG (1)