CoVid-19 - Infection and Antibody Formation in the Viennese Population

NCT04346264 | Completed

• 1 other identifier: LEAD CoVid-19
• Study Type: observational
• Target: 12,419
• Locations: 1 country
• Sites: 1

Brief Summary

Summary of the study Study population: A representative sample of the Viennese population stratified by age and gender (data from the Vienna Health Study LEAD) Potential output and analysis:

• Extent of age-specific infection and antibody formation
• Cumulative incidence of infection
• Rate of asymptomatic infection
• Relationship with socioeconomics, lifestyle and risk factors (comorbidities) Study design: Prospective, longitudinal, stratified by age and gender Duration of study: Initial testing as soon as possible and repeat based on monitoring of the pandemic curve (probably after 2-3 months) Information to be obtained from participants:
• serum samples for information on SARS-CoV2 infection and antibody formation
• data on clinical symptoms

Conditions

Virus Diseases; COVID-19

Outcome Measures

Primary Outcomes (1)

• Prevalence of SARS-CoV-2 antibody titres

  Antibody Titres IgG and IgM

  5 weeks

Secondary Outcomes (1)

• Prevalence of SARS-CoV-2 antibody titres after 3 Months

  4 Months

Study Arms (1)

General Cohort

Population general cohort from the Austrian LEAD Study

Diagnostic Test: NO intervention planned due to the observational study design only a diagnostic testing

Interventions

NO intervention planned due to the observational study design only a diagnostic testing DIAGNOSTIC_TEST

Only a diagnostic test (serum blood and antibody measurement) is planned

General Cohort

Eligibility Criteria

• Age: 6 Years - 85 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

General population cohort (The Austrian LEAD Study, NCT01727518), aged 6-85 years from Vienna, Austria

Sponsors & Collaborators

• Ludwig Boltzmann Institute for Lung Health: lead

Study Sites (1)

The LEAD Study Center

Vienna, 1140, Austria

Location

Related Publications (1)

• Breyer-Kohansal R, Faner R, Breyer MK, Ofenheimer A, Schrott A, Studnicka M, Wouters EFM, Burghuber OC, Hartl S, Agusti A. Factors Associated with Low Lung Function in Different Age Bins in the General Population. Am J Respir Crit Care Med. 2020 Jul 15;202(2):292-296. doi: 10.1164/rccm.202001-0172LE. No abstract available.

  PMID: 32255673 RESULT

Related Links

• Homepage of the Austrian LEAD Study

Biospecimen

Retention: SAMPLES WITHOUT DNA

Serum

MeSH Terms

Conditions

Virus Diseases; COVID-19

Condition Hierarchy (Ancestors)

Infections; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Otto C Burghuber, Prof.MD

  Ludwig Boltzmann Institute for Lung Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2020
• First Posted: April 15, 2020
• Study Start: April 27, 2020
• Primary Completion: May 27, 2020
• Study Completion: May 27, 2020
• Last Updated: May 4, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

AU (1)