Cervical Cord Compression and Hypertension
Effect of Cervical Compressive Myelopathy on the Autonomic Nervous System and Clinical Implication
1 other identifier
observational
100
1 country
1
Brief Summary
Myelopathy from cervical cord compression may induce hypertension and sympathetic hyperactivity. Anesthesia may suppress sympathetic activity and lead to hypotension that require vasopressor treatment. We aim to elucidate the causative factors for severe hypotension during anesthesia by prospective observational study.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2020
CompletedFirst Submitted
Initial submission to the registry
March 31, 2020
CompletedFirst Posted
Study publicly available on registry
April 14, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2021
CompletedApril 14, 2020
April 1, 2020
1.2 years
March 31, 2020
April 12, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
change of blood pressure
noninvasive blood pressure
one day before surgery, during surgery, 3 months after surgery, 6 months after surgery
change of hear rate variability
from analysis of ECG
one day before surgery, during surgery, 3 months after surgery, 6 months after surgery
baroreflex activity
from analysis of arterial blood pressure waveform
during surgery (anesthesia)
Secondary Outcomes (2)
change of Japanese Orthopaedic Association Scores
one day before surgery, 3 months after surgery, 6 months after surgery
change of the Nurick scores
one day before surgery, 3 months after surgery, 6 months after surgery
Study Arms (2)
normotension
patients without diagnosis or treatment for hypertension
hypertension
patients with diagnosis or treatment for hypertension
Interventions
The surgeries aim to relieve the myelopathy from cord compression
Eligibility Criteria
We exclude patients with other cormobidity that might lead to hypertension or hypetension. we perfrom age and gender matched pair.
You may qualify if:
- cervical spine surgery for cord compression
You may not qualify if:
- spinal cord injury
- ASA class \>3
- chronic kidney disease
- congestive heart failure
- BMI\>30
- atrial fibrillation/ flutter
- obstructive sleep apnea
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Taipei Veterans General Hospital
Taipei County, 11217, Taiwan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
MC HO, MD, PhD
Taipei Veterans General Hospital, Taiwan
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 31, 2020
First Posted
April 14, 2020
Study Start
February 1, 2020
Primary Completion
March 31, 2021
Study Completion
August 31, 2021
Last Updated
April 14, 2020
Record last verified: 2020-04