Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis

NCT04344470 | Completed

• 2 other identifiers: 20007720-N-0077
• Study Type: interventional
• Target: 39
• Locations: 1 country
• Sites: 1

Brief Summary

Background: 'Free will' can be defined as the belief that people have control over their thoughts and movements. The topic of free will is controversial and is still being debated. Science has only partial answers to questions about free will, so researchers want to learn more about it. They want to assess the role of consciousness when intentions are present with behavior. This could help to explain the causal role of consciousness in movement or decisions. Objective: To learn more about free will. Eligibility: Healthy, right-handed adults ages 25-45 Design: Participants will be screened with medical history, physical exam, and neurological exam. Participants will have 1 study visit. It will last up to 4 hours. Participants will sit in a comfortable chair in front of a screen. They will perform some or all of the following tasks. Visual Task. Participants will watch different stimuli on the screen and answer simple questions. Electroencephalography (EEG). An EEG records the electrical activity of the brain ('brain waves'). For the EEG, small electrodes are put on the scalp with an electrode cap. A gel is placed in the space between the electrodes and the scalp. Participants' brain waves will be recorded, including while they decide whether to move their thumb. Choice/Reaction Time Task. Participants will watch different stimuli on the screen and react to them by moving their wrist. During this task, they will wear an EEG cap on their head and electrodes on their arms and wrists. Electromyography. Small electrodes will be attached to participants' skin. Their muscle activity will be recorded while they decide whether to move their wrist and during the movement itself. Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive brain stimulation that uses magnetic field to stimulate nerve cells in your brain. TMS can increase or decrease brain activity in particular area of your brain. TMS operates completely outside of the body and is generally very well tolerated....

Conditions

Normal Physiology

Keywords

Healthy Volunteers

Outcome Measures

Primary Outcomes (3)

• Experiment1: Identification of the best characteristics that allow us to create a backward masking effect of the second stimulus on the first one.

  We will develop a methodological approach to create the best backward masking effect. We will ask the subjects what they saw, to prove the effectiveness of the backward masking.

  throughout

• Experiment 2: Reaction time and accuracies of the responses to different stimuli (symbols, faces, objects, etc.) in different conditions (with and without masking)

  Subjects will move to the first stimulus even if unseen. We want to study subjects behavior in different conditions (simple reaction task, choice reaction task, with and without masking) with different stimuli (symbols, faces, objects, etc.). Furthermore, we want to analyze the EEG (classic ERP, microstates, etc.) related to those stimuli. EEG will be also analyzed to study the nature and strength of the visual pathway for movement and the pathway for visual perception at rest.

  throughout

• Experiment 1: Identification of the EEG characteristic or ERP shape related to different stimuli and the brain region origin.

  We will create a template of the shape of the ERP and the characteristics of EEG related to different stimuli to be identified in the second sub-study.

  throughout

Study Arms (1)

Healthy Volunteers

EXPERIMENTAL

Healthy Volunteers

Device: EMG; Device: EEG

Interventions

EMG DEVICE

EMG will be recorded from two electrodes placed on both extensor carpi radialis (ECR) muscles

Healthy Volunteers

EEG DEVICE

EEG electrodes will be positioned according to 10-20 International System, with every impedance kept under 5 kOhm. EEG data will be amplified, filtered (DC-100 Hz), digitized at 1000 Hz, and stored on a computer for offline analysis.

Healthy Volunteers

Eligibility Criteria

• Age: 25 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• In order to be eligible to participate in this study, an individual must meet all of the following criteria:
• Age between 25-45 years
• Right-handed (tested by the Edinburg handedness inventory).
• Able to give informed consent.
• Able to comply with all study procedures.
• Fluent in English.

You may not qualify if:

• An individual who meets any of the following criteria will be excluded from participation in this study:
• Illegal drug use within the past 6 months based on history alone. The intent is to exclude those with drug use that may affect study results.
• Self-reported consumption of \>14 alcoholic drinks/week for a man and \>7 alcoholic drinks/week for a woman.
• Abnormal findings on neurological examination.
• History of current brain tumor, stroke, head trauma with loss of consciousness, epilepsy, or seizures.
• Current episode of major depression or any major psychiatric illness.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Location

Related Links

• NIH Clinical Center Detailed Web Page

MeSH Terms

Interventions

Electroencephalography

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Officials

• Lauren B Reoma, M.D.

  National Institute of Neurological Disorders and Stroke (NINDS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 11, 2020
• First Posted: April 14, 2020
• Study Start: December 22, 2020
• Primary Completion: June 26, 2023
• Study Completion: March 21, 2024
• Last Updated: April 5, 2024

Record last verified: 2024-03-21

Locations

US (1)