NCT04341376

Brief Summary

This study will examine the efficacy of Enhanced First Connections, which is a short-term perinatal home visiting program that includes infant and early childhood mental health consultation. Mothers with a history of adversity or trauma will be the focus of this research. Hypothesized outcomes of Enhanced First Connections include the prevention of child maltreatment (child abuse and neglect), prevention of child exposure to adult intimate partner violence, increases in family engagement in longer-term evidence based home visiting programs, increases in family engagement in specialized support services to address maternal adversity and trauma, reductions in maternal risk factors, and the promotion of positive parenting and the parent-child relationship.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2021

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 6, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 10, 2020

Completed
10 months until next milestone

Study Start

First participant enrolled

January 22, 2021

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2026

Completed
Last Updated

January 23, 2025

Status Verified

January 1, 2025

Enrollment Period

4.9 years

First QC Date

April 6, 2020

Last Update Submit

January 21, 2025

Conditions

Outcome Measures

Primary Outcomes (3)

  • Child Maltreatment Status

    Child protection record review

    6-months postpartum

  • Child Exposure to Intimate Partner Violence

    Child protection record review

    6-months postpartum

  • Maternal Report of Intimate Partner Violence

    Maternal report: Conflict Tactics Scales

    6-months postpartum

Secondary Outcomes (13)

  • Family engagement in evidence based home visiting programs

    6-months postpartum

  • Contextual stress exposure

    6-months postpartum

  • Maternal depressive symptoms

    6-months postpartum

  • Maternal anxiety symptoms

    6-months postpartum

  • Maternal PTSD symptoms

    6-months postpartum

  • +8 more secondary outcomes

Study Arms (2)

Enhanced First Connections

EXPERIMENTAL

Enhanced First Connections is a short-term risk assessment and response home visiting referral program. The goal of Enhanced First Connections is to identify family needs and link families to community resources, including evidence based home visiting models. Enhanced First Connections includes prenatal identification and engagement of women with an adversity or trauma history, and infant and early childhood mental health consultation. Women who enroll in Enhanced First Connections are expected to receive between four and eight home visits before being referred to other community resources.

Behavioral: Enhanced First Connections

Treatment as Usual

NO INTERVENTION

Women who receive Treatment as Usual will follow the usual course of clinical care throughout their pregnancy and into the postpartum period, and will be eligible for the typical array of community services that may be offered to them.

Interventions

Enhanced First Connections is a short-term home visiting program that includes prenatal identification and engagement of women with an adversity or trauma history, and infant and early childhood mental health consultation.

Enhanced First Connections

Eligibility Criteria

Age18 Years+
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsPregnant women
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Pregnant women
  • Recruited in the second or third trimester of pregnancy
  • At least one self-reported experience of adversity or trauma
  • English or Spanish speaking

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

E.P. Bradley Hospital

East Providence, Rhode Island, 02915, United States

Location

Study Officials

  • Stephanie H Parade, PhD

    E.P. Bradley Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 6, 2020

First Posted

April 10, 2020

Study Start

January 22, 2021

Primary Completion

January 1, 2026

Study Completion

January 1, 2026

Last Updated

January 23, 2025

Record last verified: 2025-01

Data Sharing

IPD Sharing
Will share

Final datasets generated from questionnaire, interview, and observational assessments will be cleaned and merged using SPSS syntax to generate a final dataset for analysis. A public use de-identified dataset that does not include sensitive or potentially identifiable information will be made available. For datasets that include sensitive or potentially identifiable information, data-use agreements will be put in place with appropriate restrictions prior to the provision of data. To ensure that released data have appropriate documentation, a data dictionary will accompany all de-identified datasets that includes data collection methods, measures and variable construction, and potential limitations of use.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
A de-identified dataset will be made available within 30 months following completion of the project or at the time of the publication of manuscripts that present the main aims of the study
Access Criteria
A public use de-identified dataset that does not include sensitive or potentially identifiable information will be made broadly available. For datasets that include sensitive or potentially identifiable information, data-use agreements will be put in place with appropriate restrictions prior to the provision of data.

Locations