Safety and Effectiveness of Low-flow ECMO Driving by CVVH Machine in Severe NCP
Safety and Effectiveness Study of Low Flow Extracorporeal Membrane Oxygenation（CO2 Removal） Driving by Continuous Hemofiltration Machine the Severe New Corovirus Pneumonia (NCP)
1 other identifier
interventional
10
1 country
1
Brief Summary
assess the safety and effectiveness of using low-flow extracorporeal membrane oxygenation(CO2 removal) driving by CVVH machine in the severe NCP patients
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable covid19
Started Feb 2020
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 20, 2020
CompletedFirst Submitted
Initial submission to the registry
March 3, 2020
CompletedFirst Posted
Study publicly available on registry
April 9, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 15, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
October 15, 2020
CompletedJune 16, 2020
June 1, 2020
6 months
March 3, 2020
June 13, 2020
Conditions
Outcome Measures
Primary Outcomes (3)
PaCO2
PaCO2 from blood gas analysis
Day 1
Driving Pressure
Driving Pressure monitor by ventilator
Day 1
Tidal volume
Tidal volume monitor by ventilator
Day 1
Study Arms (1)
NCP patient with severe ARDS and/or high ventilator supported
EXPERIMENTALThe NCP patient with severe ARDS and/or high ventilator supported condition was eligibilitable for enrollment
Interventions
With aim to clear CO2 and improve oxygenation, a low flow ECMO treatment(using oxgyenator membrane of kid type ) driving by CVVH machine will be performed in the NCP with severe ARDS
Eligibility Criteria
You may qualify if:
- \. NCP with severe acute respiratory distress syndrome with ratio of partial pressure of arterial oxygen over fraction of inspired oxygen (PaO2:FiO2)\<150 and PEEP \>10cmH2O
- \. Driving pressure\> 20cmH2O
- \. RR\>30bpm
- PaCO2\>55cmH2O and/or PH\>7.3
You may not qualify if:
- \. poor venous vascular condition and unavaible for central venous catheter placement
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Yun Long
Beijing, Beijing Municipality, 100730, China
Related Publications (1)
Ding X, Chen H, Zhao H, Zhang H, He H, Cheng W, Wang C, Jiang W, Ma J, Qin Y, Liu Z, Wang J, Yan X, Li T, Zhou X, Long Y, Zhang S. ECCO2R in 12 COVID-19 ARDS Patients With Extremely Low Compliance and Refractory Hypercapnia. Front Med (Lausanne). 2021 Jul 8;8:654658. doi: 10.3389/fmed.2021.654658. eCollection 2021.
PMID: 34307397DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yun Long
Peking Union Medical College Hospit
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 3, 2020
First Posted
April 9, 2020
Study Start
February 20, 2020
Primary Completion
August 15, 2020
Study Completion
October 15, 2020
Last Updated
June 16, 2020
Record last verified: 2020-06