Post-operative Pain Reduction
1 other identifier
interventional
30
1 country
1
Brief Summary
Recruited patients with necrotic pulp after application of conventional calcium hydroxide paste are assigned to group, Calcium hydroxide nanoparticle group and Combined Calcium hydroxide with silver nanoparticle group and record postoperative pain afterwards.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2020
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2020
CompletedFirst Submitted
Initial submission to the registry
April 6, 2020
CompletedFirst Posted
Study publicly available on registry
April 8, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2020
CompletedApril 8, 2020
April 1, 2020
7 months
April 6, 2020
April 6, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
change in post operative pain (Visual Analogue Scale)
Numerical (0-10)
Intrappointment at 4,24,48,72 and 96 hours ]
Study Arms (3)
Conventional calcium hydroxide paste
ACTIVE COMPARATORApplication of Conventional calcium hydroxide paste
Calcium hydroxide nanoparticle
EXPERIMENTALApplication of Calcium hydroxide nanoparticle
Combined Calcium hydroxide with silver nanoparticle
EXPERIMENTALApplication of Combined Calcium hydroxide with silver nanoparticle
Interventions
Conventional calcium hydroxide paste (Ultracal) will be removed in second visit.
Calcium hydroxide nanoparticle. manufactured in NanoTech. institute, will be removed in second visit.
Combined Calcium hydroxide with silver nanoparticle will be removed in second visit.
Eligibility Criteria
You may qualify if:
- Medically free patients.
- Patient's age between 25-50 years.
- Sex includes both male and female.
- Radiographic evidence of a periapical radiolucent lesion associated with tooth.
- Necrotic pulp as indicated by thermal pulp testing.
- No history of previous endodontic treatment of the tooth.
You may not qualify if:
- Teeth with unfavorable conditions for rubber-dam application.
- Teeth with acute periapical abscesses swelling.
- Medically compromised patients.
- Immature teeth with open apices.
- Multi rooted teeth.
- Pregnant women.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Minia Universitylead
Study Sites (1)
Faculty of Dentistry, Minia University
Minya, Egypt
Related Publications (1)
Singh RD, Khatter R, Bal RK, Bal CS. Intracanal medications versus placebo in reducing postoperative endodontic pain--a double-blind randomized clinical trial. Braz Dent J. 2013;24(1):25-9. doi: 10.1590/0103-6440201302039.
PMID: 23657409BACKGROUND
MeSH Terms
Interventions
Study Officials
- STUDY DIRECTOR
Magdy Mohamed Aly, Professor
Dean of Faculty
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Masking Details
- double
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PHD Candidate - Endodontic Department- Faculty of Dentistry
Study Record Dates
First Submitted
April 6, 2020
First Posted
April 8, 2020
Study Start
April 1, 2020
Primary Completion
November 1, 2020
Study Completion
November 1, 2020
Last Updated
April 8, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share