Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder

NCT04335175 | Completed

• 1 other identifier: 200502
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? Patients with TS, patients with OCD, and healthy controls will complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and quality of life.

Conditions

Tourette Syndrome; Obsessive-Compulsive Disorder; Sensory Disorders

Keywords

sensory dysregulation; sensory gating dysfunction; tic; obsessive compulsive; sensory symptom

Outcome Measures

Primary Outcomes (1)

• Sensory Gating Inventory

  36-item, validated self-report questionnaire assessing sensory gating symptoms, with score range 0-216. Higher scores indicate greater sensory gating impairment.

  Day 1

Secondary Outcomes (7)

• Dimensional Obsessive Compulsive Scale

  Day 1

• Adult Attention Deficit Hyperactivity Disorder Self-Report Screening Scale

  Day 1

• Generalized Anxiety Disorder-7 Scale

  Day 1

• Patient Health Questionnaire-9 Scale

  Day 1

• Premonitory Urge to Tic Scale (for Tourette syndrome patients only)

  Day 1

Study Arms (3)

Tourette Syndrome

Individuals previously diagnosed with Tourette syndrome (TS). Participants must be 18 years of age or older.

Other: None - observational study

Obsessive Compulsive Disorder

Individuals previously diagnosed with obsessive compulsive disorder (OCD). Participants must be 18 years of age or older.

Other: None - observational study

Healthy Controls

Individuals with no past or current neurologic or psychiatric illness. Participants must be 18 years of age or older.

Other: None - observational study

Interventions

None - observational study OTHER

None - observational study

Healthy Controls; Obsessive Compulsive Disorder; Tourette Syndrome

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals 18 years of age or older with Tourette syndrome and/or obsessive compulsive disorder. Individuals 18 years of age or older with no neurologic or psychiatric diagnoses.

You may qualify if:

• age 18 years or older
• previous diagnosis of Tourette syndrome and/or obsessive compulsive disorder

You may not qualify if:

• \- none
• \- 18 years of age or older
• \- history of any neurologic or psychiatric diagnoses

Sponsors & Collaborators

• Vanderbilt University Medical Center: lead

Study Sites (1)

Vanderbilt University Medical Center

Nashville, Tennessee, 37232-5400, United States

Location

MeSH Terms

Conditions

Tourette Syndrome; Obsessive-Compulsive Disorder; Sensation Disorders; Tics

Condition Hierarchy (Ancestors)

Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tic Disorders; Movement Disorders; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Neurodevelopmental Disorders; Mental Disorders; Anxiety Disorders; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Dyskinesias

Study Officials

• David Isaacs, MD, MPH

  Vanderbilt University Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Neurology

Study Record Dates

• First Submitted: April 2, 2020
• First Posted: April 6, 2020
• Study Start: April 14, 2020
• Primary Completion: February 28, 2022
• Study Completion: February 28, 2022
• Last Updated: March 15, 2022

Record last verified: 2022-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Beginning 3 months and ending 5 years following article publication.
• Access Criteria: Researchers who provide a methodologically sound proposal. Proposals should be directed to david.a.isaacs@vumc.org. To gain access, data requestors will need to sign a data access agreement.

Locations

US (1)