A Retrospective Cohort Study Outcome of Treatment in Asymptomatic Stage 4 Colorectal Cancer

NCT04334395 | Completed

• 1 other identifier: MURA2016/546
• Study Type: observational
• Target: 135
• Locations: 1 country
• Sites: 1

Brief Summary

In asymptomatic Stage 4 colorectal cancer, the treatment varies between many hospitals and countries. Some studies found that primary tumor resection had better survival rates and a lower risk of mortality. But many studies found significant benefits in survival in sub groups of the population such as age less than 70 years, WHO performance status \<2, no extra-hepatic metastasis, liver tumor burden \<50%. However some studies showed no survival benefits in primary tumor resection. So this study will focus on survival, adverse events, complications in primary tumor resection and no primary tumor resection in asymptomatic Stage 4 colorectal cancer.

Conditions

Stage IV Colon Cancer

Outcome Measures

Primary Outcomes (1)

• Complication rate

  The definition of complication defined as symptom that occurred during treatment period such as obstruction , perforation , bleeding , trenesmus.

  5 year

Secondary Outcomes (1)

• The survival time

  5 year

Interventions

primary tumor resection group PROCEDURE

resection of cancer at colon

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Medical records of stage IV colorectal cancer with unresectable distant metastasis received treatment in Ramathibodi hospital between 1 September 2006 - 31 August 2016.

You may qualify if:

• Asymptomatic stage IV colorectal cancer
• pathological prove adenocarcinoma
• age \>18 years
• no primary tumor related symptom
• ECOG performance status \<2

You may not qualify if:

• symptomatic primary tumor such as obstruction , perforation that required surgery
• carcinomatosis peritoneii
• patients with secondary cancer diagnosis in 5 years

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Chairat Supsamutchai

Bangkok, Bankok, 10400, Thailand

Location

MeSH Terms

Conditions

Colonic Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Study Officials

• Chairat Supsamutchai, MD

  270, Rama VI road, Ratchathevi, Deapartment of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2020
• First Posted: April 6, 2020
• Study Start: January 1, 2017
• Primary Completion: March 1, 2020
• Study Completion: March 31, 2020
• Last Updated: April 6, 2020

Record last verified: 2020-04

Locations

TH (1)