Bacteriological Study of Acute Follicular Tonsillitis

NCT04321733 | Unknown

• 1 other identifier: Bacteriology of Tonsillitis
• Study Type: observational
• Target: 66
• Locations: 0 countries
• Sites: N/A

Brief Summary

The objective of the study is to answer the following questions :-

1. 1.Is there an actual failure rate in tonsillitis treatment with amoxicillin clavulanate ? If yes,
2. 2.What is (are) the possible reason(s) to explain it in our locality ?

Conditions

Acute Follicular Tonsillitis

Outcome Measures

Primary Outcomes (1)

• The sensitivity of the isolated organism to amoxicillin clavulanate according to culture and sensitivity test

  throat swabs that will be taken from the tonsillar exudate, placed in sterile bottles and brought to the laboratory for Bacteriological culture of the organism and Antibiotic sensitivity tests will be done for the isolated organism(s).

  Baseline

Interventions

Amoxicillin Clavulanate DRUG

Intravenous drug intake of our drug.

Eligibility Criteria

• Age: 5 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients with acute follicular tonsillitis

You may qualify if:

• patients with acute follicular tonsillitis neither younger than five years nor older than 60 years old.

You may not qualify if:

• Other causes of tonsillitis that do not cause suppuration .
• Age below five , and above 60 years .
• Patients who received antibiotic one week before presentation .
• Immune compromised patients .
• Patients with quinsy.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Brook I. Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis. Int J Pediatr Otorhinolaryngol. 2007 Oct;71(10):1501-8. doi: 10.1016/j.ijporl.2007.06.006. Epub 2007 Jul 17.

  PMID: 17644191 BACKGROUND

• Casey JR, Pichichero ME. The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):39S-45S. doi: 10.1016/j.diagmicrobio.2006.12.020. Epub 2007 Feb 9.

  PMID: 17292576 BACKGROUND

• Sela S, Barzilai A. Why do we fail with penicillin in the treatment of group A streptococcus infections? Ann Med. 1999 Oct;31(5):303-7. doi: 10.3109/07853899908995895.

  PMID: 10574501 BACKGROUND

Related Links

• Related Info

MeSH Terms

Interventions

Amoxicillin-Potassium Clavulanate Combination

Intervention Hierarchy (Ancestors)

Clavulanic Acid; Clavulanic Acids; beta-Lactams; Lactams; Amides; Organic Chemicals; Amoxicillin; Ampicillin; Penicillin G; Penicillins; Sulfur Compounds; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Drug Combinations; Pharmaceutical Preparations

Central Study Contacts

Mena W Dous, Principal investigator

CONTACT

+201277170022; Dr_manoon@hotmail.com

Alaa K Abd El Haleem, Professor of Otolaryngology

CONTACT

+201005534200

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: March 19, 2020
• First Posted: March 25, 2020
• Study Start: April 1, 2020
• Primary Completion: April 1, 2021
• Study Completion: October 1, 2021
• Last Updated: March 25, 2020

Record last verified: 2020-03