Hypertension in Patients Hospitalized With COVID-19

NCT04318301 | Completed

• 1 other identifier: HT-COVID19
• Study Type: observational
• Target: 275
• Locations: 1 country
• Sites: 1

Brief Summary

Some studies have shown that the main pathogenesis of patients with covid19 is related to ACE2 receptor. Lung is one of the main organs, and there are many ACE2 receptors in cardiovascular system. ACEI / ARB is the main target of antihypertensive drugs. Previous reports suggested that there were large number of patients with covid19 also suffered from hypertension, suggesting that patients with hypertension may be the susceptible to covid19. Therefore, we try to follow up the patients admitted to Hankou hospital to explore the impact of hypertension and hypertension treatment on the severity and prognosis of patients with covid19, so as to provide new methods for the treatment of patients with covid19 in the future.

Conditions

COVID-19; Hypertension

Keywords

COVID-19; Hypertension; ACE2

Outcome Measures

Primary Outcomes (1)

• Rate of Death

  mortality in 28-day

  From date of admission until the date of death from any cause, up to 60 days

Secondary Outcomes (1)

• the severity of pneumonia

  From date of admission until the date of discharge or death from any cause, up to 60 days

Other Outcomes (1)

• the length of hospital stay

  From date of admission until the date of discharge or death from any cause, up to 60 days

Study Arms (2)

ACEI/ARB

COVID-19 patients with hypertension who had previously taken ACEI/ARB for antihypertensive treatment

non ACEI/ARB

COVID-19 patients with hypertension who had not previously taken ACEI/ARB for antihypertensive treatment

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with clinically confirmed COVID-19 admitted to Hankou Hospital, Wuhan, China from January 5 to March 8, 2020.

You may qualify if:

• COVID-19 pneumonia patients diagnosed by WHO criteria

You may not qualify if:

• Patients who were younger than 18 years.
• Patients whose entire stay lasted for less than 48 hours.

Sponsors & Collaborators

• Zhenhua Zen: lead

Study Sites (1)

Hankou Hospital

Hankou, Hubei, 430000, China

Location

Related Publications (6)

• Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W; China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24.

  PMID: 31978945 BACKGROUND

• Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003 Nov 27;426(6965):450-4. doi: 10.1038/nature02145.

  PMID: 14647384 BACKGROUND

• Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.

  PMID: 31986264 BACKGROUND

• Wang Z, Chen Z, Zhang L, Wang X, Hao G, Zhang Z, Shao L, Tian Y, Dong Y, Zheng C, Wang J, Zhu M, Weintraub WS, Gao R; China Hypertension Survey Investigators. Status of Hypertension in China: Results From the China Hypertension Survey, 2012-2015. Circulation. 2018 May 29;137(22):2344-2356. doi: 10.1161/CIRCULATIONAHA.117.032380. Epub 2018 Feb 15.

  PMID: 29449338 BACKGROUND

• Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005 May 24;111(20):2605-10. doi: 10.1161/CIRCULATIONAHA.104.510461. Epub 2005 May 16.

  PMID: 15897343 BACKGROUND

• Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 2004 Jun;25(6):291-4. doi: 10.1016/j.tips.2004.04.001.

  PMID: 15165741 BACKGROUND

Related Links

• A Novel Coronavirus From Patients With Pneumonia in China, 2019

Biospecimen

Retention: NONE RETAINED

Blood

MeSH Terms

Conditions

COVID-19; Hypertension

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 20, 2020
• First Posted: March 23, 2020
• Study Start: March 21, 2020
• Primary Completion: March 28, 2020
• Study Completion: March 30, 2020
• Last Updated: April 29, 2020

Record last verified: 2020-04

Locations

CN (1)