NCT04312126|Recruiting
The Beneficial Effects of Naps on Motor Learning
Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning
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Mechanisms Underlying the Beneficial Effects of Naps on Motor Learning
Sponsor study identifier
Secondary identifiers
observational
199
1 country
1
Study Start
March 4, 2021
Actual (reported)Primary Completion
March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Background: Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories. Objective: To learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill. Eligibility: English-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80 Design: Participants will be screened with:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 14, 2020
Actual (reported)March 18, 2020
Actual (reported)March 4, 2021
Actual (reported)March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The primary endpoint measure is the degree to which motor skill consolidation (i.e., offline change in correct sequence typing speed) is predicted by replay rates during wakeful rest and sleep, and spindle rates during sleep (i.e. multiple r...
The primary endpoint measure is the degree to which motor skill consolidation (i.e., offline change in correct sequence typing speed) is predicted by replay rates during wakeful rest and sleep, and spindle rates during sleep (i.e. multiple regression model with 3 predictors).
4 years
Exploratory endpoints measures are spatial (i.e. - parcellated source space) and time-frequency maps of neural replay during wakeful rest and sleep.
4 years
46 healthy young (18-35) volunteers
46 healthy older (50-80) volunteers
46 chronic (\>6 months post-stroke) stroke patients
MRI system - GE Discovery MR750 3T
MEG system The CTF MEG 275 Magnetoencephalography (MEG) scanner system
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Right-handed adults between the ages of 18 and 80.
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Leonardo G Cohen, M.D.
National Institute of Neurological Disorders and Stroke (NINDS)
First Submitted
March 14, 2020
First Posted
March 18, 2020
Study Start
March 4, 2021
Actual (reported)Primary Completion
March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Role of the Intact Hemisphere in Recovery of Motor Function After Stroke
Contact the study team to confirm eligibility.
Study Completion
March 30, 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
September 22, 2026
Record last verified: 2026-09-18
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Source: ClinicalTrials.gov.
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