NCT04307121|Completed
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Sponsor study identifier
observational
200
1 country
1
Study Start
March 10, 2020
Actual (reported)Primary Completion
December 31, 2020
Actual (reported)Study Completion
December 31, 2020
Actual (reported)Growing evidences showed that patients with chronic constipation accompanied with intestinal dysbiosis. Gut dysbiosis is a harbinger of chronic inflammation, yet the underlying basis is unclear. Plasma level of microbial translocation is a marker of mucosal permeability. Increased mucosal permeability ignites elevated microbial translocation and is a source of systemic immune activation in CKD patients. The passage of microbial components from the gastrointestinal tract into the systemic circulation may be an important contributor to the chronic inflammatory process and subsequent atherosclerosis development. We plan to determine the association constipation with biomarkers of inflammation such monocyte activation and associated cytokines as well as markers of microbial translocation including endotoxin and its antibodies, intestinal barrier proteins of 200 hemodialysis patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2020
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 10, 2020
Actual (reported)March 11, 2020
Actual (reported)March 13, 2020
Actual (reported)December 31, 2020
Actual (reported)December 31, 2020
Actual (reported)Microbial Translocation Markers
Plasma level of microbial translocation is a marker of mucosal permeability. Increased mucosal permeability ignites elevated microbial translocation and is a source of systemic immune activation in CKD patients. microbial translocation including endotoxin and its antibodies, intestinal barrier proteins
1 years
hemodialysis (HD) patients
Contact the study team to confirm eligibility.
Tungs' Taichung MetroHarbour Hospital
Taichung, Taiwan
plasma
Paik Seong Lim, PhD
Tungs' Taichung Metroharbour Hospital
200 participants (actual enrollment reported by the registry).
First Submitted
March 11, 2020
First Posted
March 13, 2020
Study Start
March 10, 2020
Actual (reported)A Caregiver-mediated Health Educational Intervention to Improve Constipation Status of Primary School Children
Primary Completion
December 31, 2020
Actual (reported)Study Completion
December 31, 2020
Actual (reported)Last Updated
February 1, 2021
Record last verified: 2021-01
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