Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study

NCT04304339 | Completed

• 1 other identifier: YETI
• Study Type: observational
• Target: 862
• Locations: 1 country
• Sites: 3

Brief Summary

Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg. Several physiopathological parameters such as respiratory minute volume, dead space volume or CO2 production influence the PaCO2. Therefore, hypercapnia can affect the time of various diseases. Available epidemiological data regarding hypercapnia are from studies investigating the efficacy of non-invasive ventilation (NIV), with different population cohorts. However, their interpretation must be cautious given the heterogeneity in patient case-mix and results. Then, whether hypercapnia is a common reason for intensive care unit (ICU) admission, epidemiological data is scarce and heterogeneous. The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

Conditions

Intensive Care Unit Syndrome; Hypercapnia; Acute Respiratory Failure

Outcome Measures

Primary Outcomes (1)

• Prevalence of hypercapnic acute respiratory failure in ICU

  Number of patients with hypercapnic acute respiratory failure in ICU related to number of patients admitted in the ICU during study period

  Intensive Care Unit length stay (Usually 7 days)

Interventions

Hypercapnic respiratory failure OTHER

Patients with hypercapnic respiratory failure will be followed without any additional intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The aim of this study is to investigate the epidemiological, clinical determinants and outcomes of patients admitted to ICU with hypercapnic respiratory failure.

You may qualify if:

• patients ≥18 years old presenting with at least of the following items :
• respiratory rate ≥ 25/min,
• paradoxical motion of the abdomen,
• intercostal retraction AND
• a PaCO2 \> 45 cm H20 before ICU admission or within the 12 hours following ICU admission.

You may not qualify if:

• Refusal to give informed consent,
• pregnancy,
• \< 18 years patient,
• dying patient

Sponsors & Collaborators

• French Society for Intensive Care: lead

Study Sites (3)

CH Andre Migniot

Versailles, A, France

Location

CHU Nantes

Nantes, France

Location

CHU Toulouse

Toulouse, France

Location

MeSH Terms

Conditions

Hypercapnia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2020
• First Posted: March 11, 2020
• Study Start: December 14, 2021
• Primary Completion: July 13, 2022
• Study Completion: July 13, 2022
• Last Updated: September 18, 2025

Record last verified: 2025-09

Locations

FR (3)