NCT04302961

Brief Summary

There is evidence to support individuals with chronic ankle instability (CAI) have altered gait biomechanics which may lead to re-injury and poor patient outcomes. Currently, there are no interventions specifically targeting these abnormal gait biomechanics. Evidence supports the use of an external focus of attention feedback to promote motor learning and retention. The overall purpose of randomized clinical trial is to determine the effects of a 2-week (8 session) gait retraining protocol using an auditory external feedback instrument can (1) alter biomechanics during functional tasks (walking, step-down, lunge, lateral hops, and balance) (2) improve ankle cartilage measures and (3) improve patient-reported outcome measures.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
28

participants targeted

Target at P50-P75 for early_phase_1

Timeline
Completed

Started Oct 2020

Shorter than P25 for early_phase_1

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 4, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 10, 2020

Completed
7 months until next milestone

Study Start

First participant enrolled

October 5, 2020

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2021

Completed
Last Updated

August 19, 2024

Status Verified

August 1, 2024

Enrollment Period

9 months

First QC Date

March 4, 2020

Last Update Submit

August 16, 2024

Conditions

Outcome Measures

Primary Outcomes (3)

  • Changes from baseline in lower extremity kinetics during walking

    Plantar pressure and center of pressure trajectory measured with an in-shoe plantar pressure system

    Immediate post-intervention, 1-week post-intervention

  • Changes from baseline in talar cartilage deformation before and after walking

    Talar cartilage thickness and cross-sectional area will be measured with an diagnostic ultrasound imaging system

    Immediate post-intervention, 1-week post-intervention

  • Changes from baseline in self-reported ankle function

    Changes from baseline in self-reported function as measured by the Foot and Ankle Ability Measure (FAAM) Activities of Daily Living and Sport questionnaire. Scores range from 100% (no decrease in function) to 0% (complete loss of function).

    Immediate post-intervention, 1-week post-intervention

Secondary Outcomes (2)

  • Changes from baseline in static balance

    Immediate post-intervention, 1-week post-intervention

  • 2. Changes from baseline in plantar pressure during forward lunges, lateral hops, and a step-down

    Immediate post-intervention, 1-week post-intervention

Study Arms (2)

Auditory Feedback

EXPERIMENTAL

Participants will complete 8 sessions over a 2-week period of walking gait retraining on a treadmill while receiving auditory feedback.

Other: Auditory Feedback

No Feedback

ACTIVE COMPARATOR

Participants will complete 8 sessions over a 2-week period of walking on a treadmill without receiving feedback.

Other: No Feedback

Interventions

Participants will complete 8 sessions over a 2-week period of walking gait retraining on a treadmill while receiving no feedback. Participants will be instructed to walk on a treadmill at their desired pace in a manner that does not cause the auditory tool to elicit a noise.

Auditory Feedback

Participants will complete 8 sessions over a 2-week period of walking gait retraining on a treadmill while receiving no feedback. Participants will be instructed to walk on a treadmill at their desired pace in a manner that they perceive to be their normal walking speed and mechanics.

No Feedback

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • History of at least one ankle sprain
  • Index ankle sprain \> 12 months prior to study enrollment
  • Most recent ankle sprain \> 12 weeks prior to study enrollment
  • Score \>10 on the Identification of Functional Ankle Instability (IdFAI) survey.
  • Score \<95% on the Foot and Ankle Ability Measure (FAAM) Activities of Daily Living and a \<85% on the Sport subscales
  • Be physically active by participating in some form of physical activity for at least 20 min per day, three times per week.

You may not qualify if:

  • History of ankle surgery
  • History of other musculoskeletal injuries within the past 6 weeks
  • Any condition affecting plantar pressure distribution
  • Neurological or vestibular disorders affecting balance
  • Current/previous self-reported disability due to lower extremity pathology that may adversely affect neuromuscular function

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UNC Charlotte

Charlotte, North Carolina, 28223, United States

Location

Related Publications (1)

  • Torp DM, Thomas AC, Hubbard-Turner T, Donovan L. Plantar pressure profile during walking is associated with talar cartilage characteristics in individuals with chronic ankle instability. Clin Biomech (Bristol). 2022 May;95:105656. doi: 10.1016/j.clinbiomech.2022.105656. Epub 2022 Apr 27.

MeSH Terms

Conditions

Ankle Injuries

Condition Hierarchy (Ancestors)

Leg InjuriesWounds and Injuries

Study Design

Study Type
interventional
Phase
early phase 1
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

March 4, 2020

First Posted

March 10, 2020

Study Start

October 5, 2020

Primary Completion

June 30, 2021

Study Completion

June 30, 2021

Last Updated

August 19, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

Locations