Strategies to Maintain Radial Artery Patency Following Diagnostic Coronary Angiography - Diagnostic Transradial Coronary Angiography Without Systemic Anticoagulatio
RAPID-1
1 other identifier
interventional
400
0 countries
N/A
Brief Summary
To investigate whether omitting systemic anticoagulation during transradial coronary angiography and/or a distal radial access reduce the risk of postprocedural radial artery occlusion
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started May 2020
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 18, 2020
CompletedFirst Posted
Study publicly available on registry
March 10, 2020
CompletedStudy Start
First participant enrolled
May 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2022
CompletedApril 24, 2020
April 1, 2020
1.4 years
February 18, 2020
April 22, 2020
Conditions
Outcome Measures
Primary Outcomes (2)
Occurrence of postprocedural RAO
Will be the occurrence of postprocedural RAO assessed with high-resolution vascular ultrasound. Experienced sonographers will perform color Doppler ultrasound in all study patients after removal of the compression device to examine the radial, ulnar, and brachial arteries of the access forearm.
Day 1
Bleeding events
Will be bleeding events according to Bleeding Academic Research Consortium (BARC) criteria.
Day 1
Secondary Outcomes (1)
Sonographic characteristics of radial artery occlusion
3 Month
Study Arms (2)
Group 1
OTHERTraditional puncture site + no anticoagulation
Group 2
OTHERTraditional puncture site + ACT-guided anticoagulation
Interventions
Traditional punkcture site and No anticoagulation
Traditional punkcture site and ACT-guided anticoagulation
Eligibility Criteria
You may qualify if:
- Clinical indication to perform diagnostic coronary angiography
- Age \> 18 years
- Written informed consent
You may not qualify if:
- Preexisting or already administered anticoagulation prior to coronary angiography
- Planned coronary intervention
- Preexisting radial artery occlusion or missing pulse at the potential puncture sites
- Allergy / intolerance to anticoagulants
- Active bleeding or comorbidity with elevated bleeding risk
- Pregnancy
- Inability to sign informed consent
- Participation in another trial
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Stiermaier T, Grunewalder M, Patz T, Rawish E, Joost A, Meusel M, Marquetand C, Kurz T, Schmidt T, Frerker C, Fuernau G, Eitel I. Distal access and procedural anticoagulation to prevent radial artery occlusion after coronary angiography - the randomised RAPID trial. EuroIntervention. 2025 Apr 7;21(7):e366-e375. doi: 10.4244/EIJ-D-24-00846.
PMID: 40191883DERIVED
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Senior physician
Study Record Dates
First Submitted
February 18, 2020
First Posted
March 10, 2020
Study Start
May 1, 2020
Primary Completion
September 30, 2021
Study Completion
June 30, 2022
Last Updated
April 24, 2020
Record last verified: 2020-04