NCT04299854

Brief Summary

In normal-weight patients, numerous studies show an equivalence of efficacy between dinoprostone and balloon to induce labor. In obese patients, this efficacy is not known, although inductions of labor are more frequent. MODOBAT aims to describe the ability to obtain a vaginal delivery of two modality of induction of labor (vaginal dinoprostone and single balloon Foley catheter) in obese women at term.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
77

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jun 2020

Shorter than P25 for all trials

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 5, 2020

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 9, 2020

Completed
3 months until next milestone

Study Start

First participant enrolled

June 11, 2020

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 12, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 12, 2020

Completed
Last Updated

May 3, 2021

Status Verified

March 1, 2021

Enrollment Period

6 months

First QC Date

March 5, 2020

Last Update Submit

April 30, 2021

Conditions

Keywords

Induction of LaborBMIObesitycaesareanC-sectionPregnancyBalloonDinoprostone

Outcome Measures

Primary Outcomes (1)

  • Cesarean sections

    Rate of cesarean sections in each group

    1 year

Secondary Outcomes (2)

  • Entry into active phase (dilation to 5-6 cm)

    1 year

  • Complication

    1 year

Study Arms (2)

Vaginal Dinoprostone

Induction of labor by 10mg of vaginal dinoprostone

Drug: Dinoprostone 10mg

Single Balloon Foley Catheter

Induction of labor by single balloon Foley catheter

Device: single balloon Foley catheter

Interventions

Vaginal delivery system containing 10mg of dinoprostone placed at the bottom of the vagina

Vaginal Dinoprostone

A single balloon Foley catheter is being inserted on transcervical and inflated above the internal cervical os

Single Balloon Foley Catheter

Eligibility Criteria

Age18 Years - 60 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Patients of the level III maternity of university hospital center of Besançon and level IIB maternity of regional hospital of Trevenans, France.

You may qualify if:

  • Age ≥ 18 years
  • Medical indication of induction of labor
  • BMI ≥ 30 kg / m2
  • Bishop \< 6
  • Singleton
  • Gestational age \> 36 SA + 6j
  • Cephalic presentation

You may not qualify if:

  • Adults under guardianship or curatorship
  • Scarred uterus
  • Placenta praevia

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

CHU Besançon

Besançon, France

Location

Hopital Nord Franche-Comté

Trévenans, France

Location

MeSH Terms

Conditions

Obesity

Interventions

Dinoprostone

Condition Hierarchy (Ancestors)

OverweightOvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Prostaglandins EProstaglandinsEicosanoidsFatty Acids, UnsaturatedFatty AcidsLipidsAutacoidsInflammation MediatorsBiological Factors

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 5, 2020

First Posted

March 9, 2020

Study Start

June 11, 2020

Primary Completion

December 12, 2020

Study Completion

December 12, 2020

Last Updated

May 3, 2021

Record last verified: 2021-03

Locations