Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease

NCT04299308 | Completed Results DMC

• 2 other identifiers: STUDY001421401R01AG062548-01A1
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal is to characterize the acute exercise response as it relates to brain glucose metabolism in aging and Alzheimer's Disease (AD). The study team will also examine lactate metabolism, relationships with cognition, and the effect of exercise intensity.

Conditions

Healthy Aging; Alzheimer Disease

Outcome Measures

Primary Outcomes (1)

• Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) Metabolism (Standard Uptake Value Ratio)

  FDG PET measures reflecting cerebral metabolism standardized to the uptake value of the cerebellum and standardized uptake value ratios (SUVR) calculated from native-space region of interest (ROI).

  Resting Vs acute exercise bout: ~1 month

Secondary Outcomes (2)

• Lactate Area Under the Curve

  Resting Vs acute exercise bout: ~1 month

• Brain-derived Neurotrophic Factor (BDNF) Change

  Resting Vs acute exercise bout: ~1 month

Study Arms (2)

Moderate Intensity Aerobic Exercise

EXPERIMENTAL

45-55% of heart rat reserve (HHR) Low range = ((Max HR from Visit 1) - Resting HR ) \* 0.45 + Resting HR High range = ((Max HR from Visit 1) - Resting HR) \* 0.55 + Resting HR

Behavioral: Aerobic Exercise

High Intensity Aerobic Exercise

EXPERIMENTAL

65-75% of heart rat reserve (HHR) Low range = ((Max HR from Visit 1) - Resting HR ) \* 0.65 + Resting HR High range = ((Max HR from Visit 1) - Resting HR) \* 0.75 + Resting HR

Behavioral: Aerobic Exercise

Interventions

Aerobic Exercise BEHAVIORAL

Participants will exercise for 15 minutes based on heart rate range. The study team will employ a stationary bike to maintain control over workload

High Intensity Aerobic Exercise; Moderate Intensity Aerobic Exercise

Eligibility Criteria

• Age: 60 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 60 and older
• Stable medication doses (\>1month)
• Post-menopausal
• Diagnosis of either Nondemented (CDR 0) or Probable AD (CDR 0.5 or 1 only)

You may not qualify if:

• Inability to provide consent
• Diagnosis of insulin-dependent (Type 1) Diabetes Mellitus
• Recent ischemic heart disease (\<2 years)
• Diagnosis of an clinically significant chronic disease including cardiovascular disease (CVD), other metabolic diseases (e.g., thyroid), cancer, human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome
• Excluded from or unable to complete an MRI scan
• Any Neurological disorders that have the potential to impair cognition or brain metabolism (e.g., Parkinson's disease, stroke defined as a clinical episode with neuroimaging evidence in an appropriate area to explain the symptoms).
• Clinically significant depressive symptoms that may impair cognition, abnormalities in B12, rapid plasma regain (RPR), or thyroid function that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment

Sponsors & Collaborators

• University of Kansas Medical Center: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

Univeristy of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location

Related Publications (2)

• Green ZD, John CS, Kueck PJ, Blankenship AE, Kemna RE, Johnson CN, Yoksh LE, Best SR, Donald JS, Mahnken JD, Burns JM, Vidoni ED, Morris JK. Acute exercise alters brain glucose metabolism in aging and Alzheimer's disease. J Physiol. 2024 Sep 11:10.1113/JP286923. doi: 10.1113/JP286923. Online ahead of print.

  PMID: 39258961 BACKGROUND

• Green ZD, John CS, Kueck PJ, Burns JM, Perry M, Donald J, Mahnken JD, Honea RA, Vidoni ED, Morris JK. Rationale and methods to characterize the acute exercise response in aging and Alzheimer's Disease: the AEROBIC pilot study. Contemp Clin Trials. 2021 Aug;107:106457. doi: 10.1016/j.cct.2021.106457. Epub 2021 May 27.

  PMID: 34051350 BACKGROUND

MeSH Terms

Conditions

Alzheimer Disease

Interventions

Exercise

Condition Hierarchy (Ancestors)

Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Results Point of Contact

• Title: Dr. Jill Morris
• Organization: University of Kansas Medical Center

jmorris2@kumc.edu

9139457675

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: 2 arm, cross-sectional

Study Record Dates

• First Submitted: March 4, 2020
• First Posted: March 6, 2020
• Study Start: August 28, 2020
• Primary Completion: October 31, 2023
• Study Completion: October 31, 2023
• Last Updated: July 23, 2025
• Results First Posted: July 23, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)