Can Physical Activities Reduce Postoperative Pain in Adults

NCT04293250 | Completed

• 1 other identifier: 104042
• Study Type: interventional
• Target: 1,600
• Locations: 0 countries
• Sites: N/A

Brief Summary

Recommendation is strong on physical activity (PA) in the prehabilitation of Enhanced Recovery After Surgery (ERAS) for various types of surgeries. The evidence is however weak regarding ERAS protocols. Many studies have showed that physical exercise and PA have hypoalgesic effects on healthy individuals and they have better pain tolerance too. Here the investigators study changes in postoperative pain and postoperative nausea and vomiting for various types of surgical patients after performing preoperative PA at moderate or vigorous intensity Vs non-preoperative PA patients.

Conditions

Postoperative Pain; Physical Activity

Keywords

postoperative pain; Physical Activity; Non-Physical Activity; Enhanced Recovery After Surgery; Prehabilitation

Outcome Measures

Primary Outcomes (1)

• The beneficial effect of physical activity on postoperative pain after various types of surgeries

  1. The pain scores different of the physical activity (PA) Vs non-physical activity (non-PA) groups are using the numeric pain rating scale (NRS) with 1 represent no pain and 5 represent the worst possible pain. 2. The severity of postoperative pain will be measured prospectively by using NRS at different postoperative time points (i.e. 1, 4, 7, 10, and 24 hour) for comparing the postoperative pain different between PA and non-PA patients.

  2 years and 6 months

Study Arms (2)

Physical activity group

EXPERIMENTAL

1. Investigators employ the recommendations of the American College of Sport Medicine and the World Health Organization for adults to divide our enrolled patients having moderate-intensity as 30-60 min∙d-1 (≥150 min∙wk-1 ) or vigorous-intensity as 20-60 min∙d-1 (≥75 min∙wk-1) for 6-8 weeks preoperatively. 2. The severity of postoperative pain are measured prospectively at 1, 4, 7, 10 and 24 hours after the surgical operations. 3. The operations are performed under inhalation general anesthesia with endotracheal intubation or through laryngeal mask.

Procedure: Compare the severity of postoperative pain of the physical activity group Vs non-physical activity group

non-physical activity group

EXPERIMENTAL

1. No any moderate-intensity or vigorous-intensity physical activity for our enrolled patients preoperatively. 2. The severity of postoperative pain are measured prospectively at 1, 4, 7, 10 and 24 hours after the surgical operations. 3. Various types of operations are performed under inhalation general anesthesia with endotracheal intubation or through laryngeal mask.

Procedure: Compare the severity of postoperative pain of the physical activity group Vs non-physical activity group

Interventions

Compare the severity of postoperative pain of the physical activity group Vs non-physical activity group PROCEDURE

Compare postoperative pain scores for the physical activity Vs non-physical activity group

Physical activity group; non-physical activity group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• aged ≥18 y/o
• Enrolled in-patients
• Patients are scheduled to undergo various operations.
• The surgeries are expected to last ≥60 minutes
• Endotracheal intubation or laryngeal mask inhalation general anesthesia.

You may not qualify if:

• Patients will transferred to the intensive care unit after operations.
• American Society of Anesthesiology physical status ≥4
• poorly controlled diabetic mellitus (HA1c ≥9)
• prolonged corrected QT interval (male ≥0.45 sec, female ≥0.47 sec)
• Allergy to any opioids (i.e., morphine, fentanyl, pethidine and others) and nonopioids (i.e., selective or nonselective NSAIDs and acetaminophen)
• Allergy to dexamethasone, granisetron, droperidol, metoclopramide used for prevention of postoperative nausea and vomiting
• Deaf or unable to speak/understand Taiwanese or Mandarin
• Failed to recall or uncertain on how many days/times they had spent doing moderate or vigorous physical activity on recent 6 to 8 weeks before receiving surgery.

Sponsors & Collaborators

• Chiayi Christian Hospital: lead

Related Publications (9)

• Pogatzki-Zahn EM, Segelcke D, Schug SA. Postoperative pain-from mechanisms to treatment. Pain Rep. 2017 Mar 15;2(2):e588. doi: 10.1097/PR9.0000000000000588. eCollection 2017 Mar.

  PMID: 29392204 BACKGROUND

• Gan TJ, Habib AS, Miller TE, White W, Apfelbaum JL. Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey. Curr Med Res Opin. 2014 Jan;30(1):149-60. doi: 10.1185/03007995.2013.860019. Epub 2013 Nov 15.

  PMID: 24237004 BACKGROUND

• Ljungqvist O, Scott M, Fearon KC. Enhanced Recovery After Surgery: A Review. JAMA Surg. 2017 Mar 1;152(3):292-298. doi: 10.1001/jamasurg.2016.4952.

  PMID: 28097305 BACKGROUND

• Milliken D, Schofield N. Understanding Prehabilitation. Anaesthesia 2018; Tutorial Of The Week 394: 1-5.

  BACKGROUND

• Jones MD, Booth J, Taylor JL, Barry BK. Aerobic training increases pain tolerance in healthy individuals. Med Sci Sports Exerc. 2014 Aug;46(8):1640-7. doi: 10.1249/MSS.0000000000000273.

  PMID: 24504426 BACKGROUND

• Naugle KM, Riley JL 3rd. Self-reported physical activity predicts pain inhibitory and facilitatory function. Med Sci Sports Exerc. 2014 Mar;46(3):622-9. doi: 10.1249/MSS.0b013e3182a69cf1.

  PMID: 23899890 BACKGROUND

• Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction With Life Scale. J Pers Assess. 1985 Feb;49(1):71-5. doi: 10.1207/s15327752jpa4901_13.

  PMID: 16367493 BACKGROUND

• Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983 Dec;24(4):385-96. No abstract available.

  PMID: 6668417 BACKGROUND

• Hu L, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Structural Equation Modeling 1999; 6(1): 1-55

  BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative; Motor Activity

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Behavior

Study Officials

• Wui-Chiu Mui, M.D., MBA

  Chiayi Christian Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: latent growth modeling using structural equation model,

Study Record Dates

• First Submitted: January 30, 2020
• First Posted: March 3, 2020
• Study Start: July 1, 2015
• Primary Completion: June 30, 2016
• Study Completion: December 31, 2017
• Last Updated: June 16, 2021

Record last verified: 2020-02

Data Sharing

• IPD Sharing: Will not share