Influence of Pb&Cd Seminal Plasma Level & ICSI

NCT04286633 | Unknown

• 1 other identifier: Pb&Cd seminal level&ICSI
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the influence of lead (pb) and cadmium (cd) seminal plasma level on embryo development and pregnancy rate during intracytoplasmic sperm injection (ICSI).

Conditions

Infertility, Male

Outcome Measures

Primary Outcomes (1)

• The influence of lead and cadmium seminal plasma level on intracytoplasmic sperm injection (ICSI) outcome

  evaluate the influence of lead (pb) and cadmium (cd) seminal plasma level on embryo development and pregnancy rate during intracytoplasmic sperm injection (ICSI).

  baseline

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

prospective cohort study to evaluate seminal plasma lead and cadmium level affects intracytoplasmic sperm injection out come

You may qualify if:

• Isolated male infertility (oligozoospermia, astenozoospermia, teratozoospermia)
• First ICSI cycle
• Female partner ≤ 35 y-old

You may not qualify if:

• Wife age \> 35 years
• Frozen semen samples
• Male partner with severe oligoasthenoteratozoospermia \<5 × 106 / mL and 5% progressive motility, included globozoospermia and pinhead samples, and surgically retrieved sperms
• Poor responder women
• Women with abnormal endometrium at hCG trigger day.
• Women with BMI \> 31
• Women with PCOS
• Previous failed ICSI
• OHSS)overian hyperstimulation syndrome)
• Patients with systemic diseases affecting fertility
• Patients on radiotherapy or receiving medications with gonadotoxic effect eg., chemotherapy

Sponsors & Collaborators

• Assiut University: lead

Related Publications (6)

• Bernard A. Cadmium & its adverse effects on human health. Indian J Med Res. 2008 Oct;128(4):557-64.

  PMID: 19106447 BACKGROUND

• Gill K, Rosiak A, Gaczarzewicz D, Jakubik J, Kurzawa R, Kazienko A, Rymaszewska A, Laszczynska M, Grochans E, Piasecka M. The effect of human sperm chromatin maturity on ICSI outcomes. Hum Cell. 2018 Jul;31(3):220-231. doi: 10.1007/s13577-018-0203-4. Epub 2018 Mar 29.

  PMID: 29594950 BACKGROUND

• Wdowiak A, Wdowiak E, Bojar I. Evaluation of trace metals in follicular fluid in ICSI-treated patients. Ann Agric Environ Med. 2017 Jun 23;25(2):213-218. doi: 10.26444/aaem/75422. Epub 2017 Jun 23.

  PMID: 29936824 BACKGROUND

• Kumar S, Mishra VV. Review: Toxicants in reproductive fluid and in vitro fertilization (IVF) outcome. Toxicol Ind Health. 2010 Sep;26(8):505-11. doi: 10.1177/0748233710373081. Epub 2010 Jun 7.

  PMID: 20529961 BACKGROUND

• Kruger TF, Menkveld R, Stander FS, Lombard CJ, Van der Merwe JP, van Zyl JA, Smith K. Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril. 1986 Dec;46(6):1118-23. doi: 10.1016/s0015-0282(16)49891-2.

  PMID: 2946611 BACKGROUND

• Tong S, Von Schirnding YE, Prapamontol T. [Environmental lead exposure: a public health problem with global dimensions]. Servir. 2000 Jan-Feb;49(1):35-43. No abstract available. Portuguese.

  PMID: 12029976 BACKGROUND

MeSH Terms

Conditions

Infertility, Male

Condition Hierarchy (Ancestors)

Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Infertility; Male Urogenital Diseases

Central Study Contacts

Shaimaa Abdul-Rahman, master student

CONTACT

01129239512; dr.shaimaa2021@gmail.com

Ali Mahran, professor doctor

CONTACT

01223971344; alimahran@aun.adu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: February 25, 2020
• First Posted: February 27, 2020
• Study Start: May 1, 2022
• Primary Completion: November 1, 2022
• Study Completion: December 1, 2022
• Last Updated: July 23, 2021

Record last verified: 2021-07