NCT04286022

Brief Summary

This study aims to apply a novel study methodology using high density electromyography (HDEMG) to know what are the mechanisms underlying the structural and functional changes obtained by two different training methods, commonly used, facilitating their understanding, study and subsequent application according to specific needs.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
34

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 24, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 26, 2020

Completed
2.8 years until next milestone

Study Start

First participant enrolled

January 1, 2023

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2023

Completed
1 day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 31, 2023

Completed
Last Updated

December 7, 2023

Status Verified

February 1, 2023

Enrollment Period

10 months

First QC Date

February 24, 2020

Last Update Submit

November 30, 2023

Conditions

Keywords

Strength trainingNeuromuscular adaptation

Outcome Measures

Primary Outcomes (1)

  • Change from Baseline Mean Discharge Rate of Brachialis Biceps Motor Units at 4 weeks

    The mean discharge rate of the Brachialis Biceps motor units will be evaluated using a high density electromyography device (HDEMG). For this, the signal produced during isometric contractions at different submaximal force levels (10, 30, 50, and 70%) will be recorded, using an external analog to digital signal converter Sessantaquattro (64-channel EMG amplifier; OT Bioelettronica, Turin, Italy).

    Baseline and post-intervention (4 weeks after baseline)

Secondary Outcomes (5)

  • Speed of propagation of Brachialis Biceps Motor Units

    Baseline and post-intervention (4 weeks after baseline)

  • Isometric force of Brachialis Biceps using hand dynamometer

    Baseline and post-intervention (4 weeks after baseline)

  • Isometric force of Brachialis Biceps using s-beam load cell

    Baseline and post-intervention (4 weeks after baseline)

  • Muscle thickness (thickness) of the brachial biceps using ultrasound

    Baseline and post-intervention (4 weeks after baseline)

  • Arm circumference

    Baseline and post-intervention (4 weeks after baseline)

Study Arms (2)

Speed Loss 20% Group

EXPERIMENTAL

The SL20% group will carry out a program based on the limitation of the speed loss, allowing to perform the exercise only until a speed loss of 20% is achieved, following a similar methodology previously published (Pareja-Blanco et al., 2017). The program will consist of a job for 4 weeks, with a frequency of 2 sessions a week. In each session, a 6-series routine with an open number of repetitions will be carried out twice, allowing as many repetitions as possible to perform until a 20% loss of execution speed is reached. The intensity of work will be 70% 1RM, resting 4 minutes between sets. As an only exercise, an elbow flexion (bicep curl) with dumbbell will be performed.

Other: Speed Loss 20% Strength Training

Reduced Rest Time Group

EXPERIMENTAL

The RRT group will carry out a program based on the reduction of rest time between series, following a previously published methodology (Stragier et al., 2019). The program will consist of a job for 4 weeks, with a frequency of 2 sessions a week. In each session, a 5 series routine with progressive repetition volume (3 to 7) at 70% 1RM will be performed twice, resting 15 seconds between sets and 150 seconds between each of the 2 blocks. The exercise to be performed will be an elbow flexion (bicep curl) with dumbbell.

Other: Reduced Rest Time Strength Training

Interventions

Strength training based on the control of speed loss in execution.

Speed Loss 20% Group

Strength training based on a protocol that includes reduced rest times between sets.

Reduced Rest Time Group

Eligibility Criteria

Age18 Years - 35 Years
Sexmale(Gender-based eligibility)
Gender Eligibility DetailsRecruitment will be done only among men because of the need to use a homogeneous sample due to the heterogeneity of the test itself. Previous studies have shown a greater possibility of data analysis in men when using HDEMG.
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • years
  • men

You may not qualify if:

  • physical exercise that involves work of upper limbs during the time of the intervention
  • upper limb injury during the previous 12 months
  • systemic diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Health Science School , University of Malaga

Málaga, 29009, Spain

Location

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Antonio I Cuesta-Vargas, PhD

    University of Malaga

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
The assessor will not be aware of the group to which each subject has been assigned.
Purpose
OTHER
Intervention Model
PARALLEL
Model Details: Two randomly allocated parallel groups
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director, Clinical Research

Study Record Dates

First Submitted

February 24, 2020

First Posted

February 26, 2020

Study Start

January 1, 2023

Primary Completion

October 30, 2023

Study Completion

October 31, 2023

Last Updated

December 7, 2023

Record last verified: 2023-02

Locations