Urinary Biomarkers of Renal Injury in Inflammatory Bowel Disease
Urinary Nephrin and Alpha One Microglobulin as Early Renal Injury Biomarkers in Patients With Inflammatory Bowel Disease
1 other identifier
observational
100
0 countries
N/A
Brief Summary
The study aims to early detection of renal injury in patients diagnosed to have inflammatory bowel disease with normal kidney function test focusing on glomerular filtration barrier injury and tubular injury and it's relation to disease activity so precautions could be taken properly to prevent further renal injury later on .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 21, 2020
CompletedFirst Posted
Study publicly available on registry
February 25, 2020
CompletedStudy Start
First participant enrolled
March 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2021
CompletedFebruary 25, 2020
February 1, 2020
1.7 years
February 21, 2020
February 24, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Early detection of renal injury in patients diagnosed to have inflammatory bowel disease with normal kidney function
using urinary biomarkers (nephrin and alpha one microglobulin ) for early detection of renal injury in inflammatory bowel disease patients
baseline
Study Arms (2)
patients with chron's disease
patients with ulcerative cholitis
Interventions
urinary nephrin and alpha one microglobulin are biomarkers of glomerular filtration barrier injury and tubular injury respectively measured by ELISA
Eligibility Criteria
inflammatory bowel disease patients aging more than 18 with no concomitent kidney disease
You may qualify if:
- \- Patients diagnosed to have inflammatory bowel disease (ulcerative colitis or chron's disease )with age more than 18 years and normal kidney function test
You may not qualify if:
- Patients known to have renal disease due to other causes . Diabetic patients . Hypertensive patients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Akankwasa G, Jianhua L, Guixue C, Changjuan A, Xiaosong Q. Urine markers of podocyte dysfunction: a review of podocalyxin and nephrin in selected glomerular diseases. Biomark Med. 2018 Aug;12(8):927-935. doi: 10.2217/bmm-2018-0152. Epub 2018 Jul 6.
PMID: 29976076BACKGROUNDChang CJ, Wang PC, Huang TC, Taniguchi A. Change in Renal Glomerular Collagens and Glomerular Filtration Barrier-Related Proteins in a Dextran Sulfate Sodium-Induced Colitis Mouse Model. Int J Mol Sci. 2019 Mar 22;20(6):1458. doi: 10.3390/ijms20061458.
PMID: 30909435BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- assistant lecturer
Study Record Dates
First Submitted
February 21, 2020
First Posted
February 25, 2020
Study Start
March 1, 2020
Primary Completion
November 1, 2021
Study Completion
December 1, 2021
Last Updated
February 25, 2020
Record last verified: 2020-02