NCT04282369

Brief Summary

Evaluation Of The Efficacy Of Four Different Non-invasive Ventilation Modes Performed In The Delivery Room In Late Preterm And Term Infants Wıth Respiratory Distress

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2020

Shorter than P25 for not_applicable

Geographic Reach
1 country

2 active sites

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 17, 2020

Completed
1 day until next milestone

Study Start

First participant enrolled

February 18, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 24, 2020

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2020

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 15, 2020

Completed
Last Updated

February 24, 2020

Status Verified

February 1, 2020

Enrollment Period

6 months

First QC Date

February 17, 2020

Last Update Submit

February 21, 2020

Conditions

Keywords

respiratory distress, newborn, noninvasive ventilation

Outcome Measures

Primary Outcomes (1)

  • Silverman Score

    The respiratory status of the newborns will be evaluated with the scoring system defined by Silverman.

    6 months

Secondary Outcomes (1)

  • N-PASS score

    6 months

Study Arms (4)

HHFNC

ACTIVE COMPARATOR

In this group patients will receive respiratory support by high flow nasal cannula.

Device: HHHFNC

nCPAP

ACTIVE COMPARATOR

In this group patients will receive respiratory support by nasal CPAP.

Device: NCPAP

nIPPV

ACTIVE COMPARATOR

In this group patients will receive respiratory support by nasal IPPV.

Device: NIPPV

nHFO

ACTIVE COMPARATOR

In this group patients will receive respiratory support by nasal high frequency oscillatory. ventilation.

Device: NHFO

Interventions

HHHFNCDEVICE

noninvasive ventilation modality

HHFNC
NCPAPDEVICE

noninvasive ventilation modality

nCPAP
NIPPVDEVICE

noninvasive ventilation modality

nIPPV
NHFODEVICE

noninvasive ventilation modality

nHFO

Eligibility Criteria

AgeUp to 2 Hours
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • late preterm and term infants with respiratory distress

You may not qualify if:

  • intubation for the respiratory distres.
  • major abnormalities

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Kanuni Sultan Suleyman Research and Training Hospital

Istanbul, 34065, Turkey (Türkiye)

COMPLETED

Kanuni Sultan Suleyman Research and Training Hospital

Istanbul, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Respiration DisordersRespiratory InsufficiencyDyspnea

Condition Hierarchy (Ancestors)

Respiratory Tract DiseasesSigns and Symptoms, RespiratorySigns and SymptomsPathological Conditions, Signs and Symptoms

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Neonatologist

Study Record Dates

First Submitted

February 17, 2020

First Posted

February 24, 2020

Study Start

February 18, 2020

Primary Completion

August 1, 2020

Study Completion

December 15, 2020

Last Updated

February 24, 2020

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will not share

Locations