Impact of Tooth Loss and Denture on Oral Senses and Food Preferences

NCT04281056 | Recruiting

• 1 other identifier: APHP190340
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Tooth loss impacts taste abilities and food intake. Present study aims at pertaining the impact of teeth loss and the replacement by means of complete denture on taste and trigeminal abilities, and on food preferences, and taste appetence.

Conditions

Tooth-loss

Keywords

Teeth loss; edentulousness; denture; tast; trigeminal senses; oral sensory ability

Outcome Measures

Primary Outcomes (1)

• taste detection thresholds

  Using an Electrogustometer

  up to 30 days

Secondary Outcomes (4)

• Chemical taste identification ability

  up to 30 days

• Quantitative sensory testing

  up to 30 days

• Food preferences and selectivity

  up to 30 days

• Taste appetence

  up to 30 days

Study Arms (2)

Control

NO INTERVENTION

Tooth removal

EXPERIMENTAL

Tooth removal and their replacement by means of a denture Teeth have been removed and replaced by means of dentures for at least one year

Procedure: Tooth removal and their replacement by means of a denture

Interventions

Tooth removal and their replacement by means of a denture PROCEDURE

Teeth have been removed and replaced by means of dentures for at least one year

Tooth removal

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Study Group : being completely edentulous and wearing denture for at least one year, wearing denture during meals, with clean and stable dentures. Controls:
• controls Group : dentate subjects (25 teeth at leas, non endodontically treated) with molars in Angle's Class I occlusion, having no functional disturbance of mastication and not undergoing dental treatment at the time of the recording. Matched with subjects of the study group for age, sex, tabacco consumption, and saliva flow rate.

You may not qualify if:

• Aged under 18 or over 80 Y,
• not consenting to participate
• suffering from dental
• periodontal or gum pain for the last month.

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Service odontologie Hôpital Rothschild

Paris, 75002, France

RECRUITING

MeSH Terms

Conditions

Anodontia

Interventions

Tooth Extraction

Condition Hierarchy (Ancestors)

Tooth Abnormalities; Stomatognathic System Abnormalities; Stomatognathic Diseases; Tooth Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Oral Surgical Procedures; Surgical Procedures, Operative; Dentistry

Study Officials

• Adeline Braud, Doctor

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Adeline Braud, Doctor

CONTACT

01 40 19 39 87; adeline.braud@aphp.fr

Yves Boucher, Professor

CONTACT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 20, 2020
• First Posted: February 21, 2020
• Study Start: March 16, 2022
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): April 1, 2027
• Last Updated: December 19, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)