End-range Mobilization on Knee Osteoarthritis

NCT04270253 | Completed

• 1 other identifier: PozsgaiMMaitlandKnee
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Different manual therapy techniques and conservative therapy have been used separately for alleviation of pain and improvement of physical function in patients with knee osteoarthritis (KOA). However, no study has reported the effect of combination of these treatment modalities in the management of KOA. The aim of this study was to investigate the effect of end-range mobilization added to conservative therapy versus conservative therapy alone on decrease of pain and improvement of functional status in KOA.

Conditions

Osteo Arthritis Knee

Keywords

Musculoskeletal Manipulations; Osteoarthritis, Knee; Conservative Treatment

Outcome Measures

Primary Outcomes (1)

• general pain intensity

  measuring of general pain intensity with Visual Analogue Scale

  at the end of the 3-week rehabilitation

Secondary Outcomes (8)

• pain intensity during getting up from a chair

  at the end of the 3-week rehabilitation

• pain intensity during getting in car

  at the end of the 3-week rehabilitation

• pain intensity during turning while walking

  at the end of the 3-week rehabilitation

• pain intensity during stair descending

  at the end of the 3-week rehabilitation

• Flexion and extension passive range of motion

  at the end of the 3-week rehabilitation

Study Arms (2)

End-range mobilization

EXPERIMENTAL

End-range mobilization applied 6 times for 2\*2 min in end-range of flexion and extension end-range of the tibiofemoral and patellofemoral joint beside the same conservative therapy, as used for the Control

Procedure: Conservative therapy; Procedure: Manual therapy

Control

ACTIVE COMPARATOR

Conservative therapy including aquatic exercises (5-times), land-based exercises (3-times), balneotherapy (5-times) and TENS therapy (3-times)

Procedure: Conservative therapy

Interventions

Conservative therapy PROCEDURE

Conservative therapy including aquatic exercises, land-based exercises, balneotherapy, TENS therapy

Control; End-range mobilization

Manual therapy PROCEDURE

End-range mobilization

End-range mobilization

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• KOA according to the American College of Rheumatology
• categorization as End Of Range Problem based on Maitland's classification.
• at least half year existing and at least 3 pain scores measured with Visual Analogue Scale (VAS) during weight-bearing activities
• bilateral, moderate-to-severe symptomatic tibiofemoral knee OA with radiographic evidence
• at least 90 degree passive knee flexion range
• sufficient mental status

You may not qualify if:

• acute inflammation of the knee
• intraarticular injections within the last 3 months
• total knee replacement in the opposite side
• class II. obesity (body mass index, BMI\>35kg/m2)
• severe degenerative lumbar spine disease (e.g. spondylolisthesis)
• systemic inflammatory arthritic or neurological condition
• physiotherapy and other balneotherapy attendance within 6 months
• contraindication for conservative and manual therapy
• unstable heart condition
• complex regional pain syndrome

Sponsors & Collaborators

• University of Pecs: lead

Study Sites (1)

Zsigmondy Vilmos Spa and Balneological Hospital of Harkány

Harkány, Please Select, 7815, Hungary

Location

Related Publications (3)

• Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G, Tugwell P; American College of Rheumatology. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012 Apr;64(4):465-74. doi: 10.1002/acr.21596.

  PMID: 22563589 BACKGROUND

• McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM, Underwood M. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014 Mar;22(3):363-88. doi: 10.1016/j.joca.2014.01.003. Epub 2014 Jan 24.

  PMID: 24462672 BACKGROUND

• Maricar N, Shacklady C, McLoughlin L. Effect of Maitland mobilization and exercises for the treatment of shoulder adhesive capsulitis: a single-case design. Physiother Theory Pract. 2009 Apr;25(3):203-17. doi: 10.1080/09593980902776654.

  PMID: 19384739 BACKGROUND

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Conservative Treatment; Musculoskeletal Manipulations

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Therapeutics; Complementary Therapies; Physical Therapy Modalities; Rehabilitation

Study Officials

• Miklós Pozsgai

  Zsigmondy Vilmos Spa and Balneological Hospital of Harkány

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 12, 2020
• First Posted: February 17, 2020
• Study Start: February 12, 2020
• Primary Completion: February 12, 2020
• Study Completion: May 12, 2020
• Last Updated: November 3, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

HU (1)