NCT04267510

Brief Summary

The etiology of osteoarthritis is varied, ranging from multifactorial, environmental to monogenic. In individuals in whom osteoarthritis appears earlier than in the general population, it is called early osteoarthritis. To our knowledge, there are no large-scale genetic studies on people with early osteoarthritis. The investigators therefore sought to study the causes of monogenic osteoarthritis in people suffering from early non-syndromic osteoarthritis. Material and method From 2013 to 2019, experts in constitutional bone disease sent patients with non-syndromic early osteoarthritis for genetic analysis to our center of competence for constitutional bone diseases. The sequencing of a panel of genes was carried out by NGS.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
65

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jan 2013

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2013

Completed
6.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2019

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2020

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

February 7, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 13, 2020

Completed
Last Updated

February 13, 2020

Status Verified

February 1, 2020

Enrollment Period

6.9 years

First QC Date

February 7, 2020

Last Update Submit

February 11, 2020

Conditions

Early Osteoarthritis

Keywords

genetic sequencing

Outcome Measures

Primary Outcomes (2)

  • identification of genetic mutation

    sequencing out by NGS

    1 day

  • number of genetic mutation

    sequencing out by NGS

    1 day

Eligibility Criteria

Age7 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients with early osteoarthritis who have undergone genetic sequencing

You may qualify if:

  • \- Patients with early osteoarthritis who have undergone genetic sequencing

You may not qualify if:

  • \- Patients refusing to participate in research

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UH Montpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • David GENEVIEVE

    Department of Medical Genetics

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
OTHER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 7, 2020

First Posted

February 13, 2020

Study Start

January 1, 2013

Primary Completion

December 1, 2019

Study Completion

January 1, 2020

Last Updated

February 13, 2020

Record last verified: 2020-02

Locations

FR(1)