NCT04263129|Completed
Tracheobronchial Bioengineering Using Aortic Matrices for Airway Reconstruction
TRITON
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TRITON
Sponsor study identifier
observational
35
1 country
1
Study Start
July 1, 2019
Actual (reported)Primary Completion
October 31, 2021
Actual (reported)Study Completion
October 31, 2021
Actual (reported)A technic of tracheal, carinal or bronchial transplantation using a stented cryopreserved aortic has been implemented by Pr E. Martinod in his thoracic surgery dept. The purpose of this study is to analyze the records of all the patients who have benefited from this treatment.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 31, 2021
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 1, 2019
Actual (reported)November 22, 2019
Actual (reported)February 10, 2020
Actual (reported)October 31, 2021
Actual (reported)October 31, 2021
Actual (reported)Assessment of survival at 3 months
Rate of death at 3 months
3 months
Assessment of survival at 12 months
12 months
Assessment of survival at 60 months
60 months
Radical resection of the lesions was performed using standard surgical techniques. After resection, airway reconstruction was performed using a human cryopreserved (-80°C) aortic allograft, which was not matched by the ABO and leukocyte antigen systems. To prevent airway collapse, a custom-made stent was inserted into the allograft. In patients with proximal lung tumors, the lung-sparing intervention of bronchial transplantation was used.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
All patients treated by human cryopreserved (-80°C) aortic allograft in thoracic surgery dept of Avicenne Hospital, Bobigny, France
Hopital AVICENNES Service de Chirurgie Thoracique
Bobigny, 93000, France
Martinod E, Onorati I, Radu DM, Santos Portela AM, Peretti M, Bardet J, Maiolino E, Lo Torto S, Uzunhan Y, Freynet O, Chouahnia K, Duchemann B, Brillet PY, Clero D, Juvin C, Lebreton G, Rouard H, Kabbani J, Maurer C, Gauthier A, Mangiapan G, Dutau H, Marquette CH, Malet J, Deslee G, Galvaing G, Chadeyras JB, Tronc F, Gandher C, Buffet C, Bensidhoum M, Miyara M, Dard N, Besnard V, Planes C, Tresallet C, Fournier C, Venissac N, Huet O, Beloucif S, Vicaut E. Tracheobronchial Replacement Using Cryopreserved Aortic Allografts: Results in 50 Patients (TRITON-01 Registry). Eur J Cardiothorac Surg. 2026 Jan 6;68(1):ezaf445. doi: 10.1093/ejcts/ezaf445.
Onorati I, Radu DM, Portela AMS, Peretti M, Guiraudet P, Bardet J, Freynet O, Didier M, Uzunhan Y, Chouahnia K, Duchemann B, Bourinet V, Dutau H, Berthet JP, Marquette CH, Tronc F, Sanchez ML, Tresallet C, Fournier C, Venissac N, Miyara M, Vicaut E, Martinod E. Preliminary results in tracheal replacement using stented aortic matrices for primary extensive tracheal cancer. JTCVS Tech. 2023 Jun 23;21:227-236. doi: 10.1016/j.xjtc.2023.05.021. eCollection 2023 Oct.
35 participants (actual enrollment reported by the registry).
First Submitted
November 22, 2019
First Posted
February 10, 2020
Study Start
July 1, 2019
Actual (reported)Comparison of iGel and THRIVE on Bronchoscopic Interventions
Contact the study team to confirm eligibility.
Martinod E, Radu DM, Onorati I, Portela AMS, Peretti M, Guiraudet P, Destable MD, Uzunhan Y, Freynet O, Chouahnia K, Duchemann B, Kabbani J, Maurer C, Brillet PY, Fath L, Brenet E, Debry C, Buffet C, Leenhardt L, Clero D, Julien N, Venissac N, Tronc F, Dutau H, Marquette CH, Juvin C, Lebreton G, Cohen Y, Zogheib E, Beloucif S, Planes C, Tresallet C, Bensidhoum M, Petite H, Rouard H, Miyara M, Vicaut E. Airway replacement using stented aortic matrices: Long-term follow-up and results of the TRITON-01 study in 35 adult patients. Am J Transplant. 2022 Dec;22(12):2961-2970. doi: 10.1111/ajt.17137. Epub 2022 Jul 14.
Primary Completion
October 31, 2021
Actual (reported)Study Completion
October 31, 2021
Actual (reported)Last Updated
October 18, 2022
Record last verified: 2022-10
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Source: ClinicalTrials.gov.
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