NCT04261153

Brief Summary

Numerous studies have shown the impact of anti-cancer treatments on cognition and more particularly that of chemotherapy. Elderly patients also seem to be at higher risk of developing cognitive impairment. These disorders can have a particularly negative impact in this population, in particular by having repercussions on the observance of oral treatments or even on autonomy. However, investigators still have little data concerning the management of cognitive disorders induced by oncology treatments, particularly in the elderly patient. It is therefore necessary to offer care adapted to this population which will allow the reduction of the sequelae induced by cancer treatments and the improvement of the quality of life of elderly patients.Although there are no preventive measures yet, recent studies of young women being treated for breast cancer with a cognitive complaint have shown a beneficial effect of cognitive stimulation on these cognitive disorders. Stimulation programs of this type have been developed in electronic format. However, to date, they have not been the subject of specific studies with elderly patients in whom the use of computer interface can be an obstacle.Sponsor propose to set up a study aimed at evaluating the feasibility of using cognitive stimulation software on tablets with elderly patients.The HAPPYNeuron® software, developed by a French team of neurologists, speech-language pathologists and psychiatrists, offers exercises to be performed online to stimulate the cognitive functions most impaired by oncological treatments (memory, attention, executive functions and speed of treatment).For this feasibility study, the sponsor plan to include 50 patients aged 70 and over to have them test the acceptance of cognitive stimulation by this software with a tablet interface.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
55

participants targeted

Target at P25-P50 for not_applicable breast-cancer

Timeline
Completed

Started Jun 2020

Typical duration for not_applicable breast-cancer

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 6, 2020

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 7, 2020

Completed
4 months until next milestone

Study Start

First participant enrolled

June 5, 2020

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 8, 2022

Completed
2.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 31, 2024

Completed
Last Updated

August 9, 2024

Status Verified

August 1, 2024

Enrollment Period

1.8 years

First QC Date

February 6, 2020

Last Update Submit

August 7, 2024

Conditions

Keywords

Cognition

Outcome Measures

Primary Outcomes (1)

  • Acceptance rate

    Satisfaction questionnary (Patient satisfaction questionnary; minimum 1 to maximum 5; 8 questions)

    between inclusion to 1 week

Study Arms (1)

cognitive stimulation

OTHER

3 cognitive stimulation sessions in total from the HAPPYNeuron® software, approximately 20 minutes each and spread over several days

Other: Cognitive stimulation

Interventions

3 cognitive stimulation sessions in total from the HAPPYNeuron® software, approximately 20 minutes each and spread over several days

cognitive stimulation

Eligibility Criteria

Age70 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • Patient with breast cancer, aged 70 and over,
  • During treatment with chemotherapy, targeted therapy or radiotherapy.
  • Whatever the stage of the disease,
  • Hospitalised in a week hospital, in traditional hospitalisation for an intercurrent episode or day hospitalisation, or undergoing radiotherapy
  • Absence of major cognitive impairment preventing cognitive tests (compliance with the MoCA score threshold based on the patient's age and educational level according to GRECOGVASC standards),
  • Patient with education level 3 "end of primary education" minimum (Barbizet scale),
  • Mastery of the French language,
  • Patient who signed the consent to participate in the study.

You may not qualify if:

  • Hospitalization for neurological reasons (e.g. confusion), or psychiatric,
  • Documented brain metastases,
  • History of brain radiation therapy,
  • Progressive psychiatric pathology or known dementia,
  • Abuse of alcohol or drug use,
  • Severe visual and / or hearing loss,
  • Patient's refusal to participate,
  • Patient deprived of liberty or under guardianship.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Centre François Baclesse

Caen, 14076, France

Location

Centre Henri Becquerel

Rouen, France

Location

Related Publications (1)

  • Binarelli G, Lange M, Santos MD, Duivon M, Capel A, Fernette M, Boue A, Grellard JM, Tron L, Ahmed-Lecheheb D, Clarisse B, Rigal O, Le Fel J, Joly F. Digital cognitive stimulation in elderly breast cancer patients: the Cog-Tab-Age feasibility study. BMC Complement Med Ther. 2024 May 31;24(1):209. doi: 10.1186/s12906-024-04507-0.

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
OTHER
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 6, 2020

First Posted

February 7, 2020

Study Start

June 5, 2020

Primary Completion

March 8, 2022

Study Completion

May 31, 2024

Last Updated

August 9, 2024

Record last verified: 2024-08

Data Sharing

IPD Sharing
Will not share

Locations