Preoperative Mechanical Bowel Preparation With Oral Antibiotics Reduces Surgical Site Infection After Elective Colorectal Surgery for Malignancies: a Propensity Matching Analysis
Sponsor study identifier
Secondary identifiers
OTHER · Sun Yat-sen University 5010 clinical program
observational
806
0 countries
N/A
Study Start
January 1, 2011
Actual (reported)Primary Completion
December 31, 2017
Actual (reported)Study Completion
May 12, 2019
Actual (reported)Surgical site infections (SSIs) are a major postoperative complication after colorectal surgery. Current study aims to evaluate prophylactic function of oral antibiotic intake (OA) in combination with mechanical bowel preparation (MBP) relative to MBP alone with respect to postoperative SSIs incidence. A retrospective analysis of eligible patients was to conducted using the databases of the Gastrointestinal Surgery Centre, Third Affiliated Hospital of Sun Yat-sen University from 2011 to 2017. Data pertaining to postoperative hospital stay length, expenses, SSIs incidence, anastomotic fistula incidence, and rates of other complications wloud be extracted and compared. A propensity analysis was conducted to minimize bias associated with demographic characteristics.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 12, 2019
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 1, 2011
Actual (reported)December 31, 2017
Actual (reported)May 12, 2019
Actual (reported)February 3, 2020
Actual (reported)February 6, 2020
Actual (reported)SSIs incidence
Surgical site infection incidence
up to 30 days postoperatively
length of hospital stays
up to 3 months posteroperatively
Either polyethylene glycol or magnesium sulphate was adopted as laxative one day before surgery. Clyster was conducted on surgery morning. Streptomycin 1g plus metronidazole 0.2g was prescribed 3 times a day for 3 days before surgery in the OA+MBP group patients.
Either polyethylene glycol or magnesium sulphate was adopted as laxative one day before surgery. Clyster was conducted on surgery morning. No oral antibiotics was administered to the patients.
Either polyethylene glycol or magnesium sulphate was adopted as laxative one day before surgery. Clyster was conducted on surgery morning. Streptomycin 1g plus metronidazole 0.2g was prescribed 3 times a day for 3 days before surgery in the OA+MBP group patients.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Eligible patients were identified by searching the database of the Gastrointestinal Surgery Centre, Third Affiliated Hospital of Sun Yat-sen University from 2011 to 2017.
Lei P, Ruan Y, Yang X, Wu J, Hou Y, Wei H, Chen T. Preoperative mechanical bowel preparation with oral antibiotics reduces surgical site infection after elective colorectal surgery for malignancies: results of a propensity matching analysis. World J Surg Oncol. 2020 Feb 11;18(1):35. doi: 10.1186/s12957-020-1804-4.
806 participants (actual enrollment reported by the registry).
First Submitted
February 3, 2020
First Posted
February 6, 2020
Study Start
January 1, 2011
Actual (reported)Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy
Contact the study team to confirm eligibility.
Primary Completion
December 31, 2017
Actual (reported)Study Completion
May 12, 2019
Actual (reported)Last Updated
February 6, 2020
Record last verified: 2020-02
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Source: ClinicalTrials.gov.
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