Pathological Crystallization of Cholesterol in Atherosclerosis
1 other identifier
observational
50
0 countries
N/A
Brief Summary
Endarterectomy of the carotid artery procedure will be performed at Sheba Medical center vascular surgery department, followed by fixation and histology. Tissues will then be transferred to Weizmann Institute of Science for observation implementing advanced electron microscopy techniques. Finally, joint evaluation of the results will be carried out, in relation to the patient clinical history.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started May 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 4, 2020
CompletedFirst Posted
Study publicly available on registry
February 6, 2020
CompletedStudy Start
First participant enrolled
May 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
June 30, 2021
CompletedFebruary 6, 2020
February 1, 2020
Same day
February 4, 2020
February 4, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
crystallization of cholesterol in atherosclerosis
Understand the interrelation between structural, morphological and spatial characteristics of cholesterol crystals found within the atherosclerotic lesion and its maturation and destabilization.
3 years
Interventions
carotid endarterctomy that is being used for carotid stenosis disease
Eligibility Criteria
patients with carotid stenosis - symptomatic and asymptomatic
You may qualify if:
- all patients that are being operated on for carotid endarterctomy due to carotid stenosis
You may not qualify if:
- none
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Sheba Medical Centerlead
- Weizmann Institute of Sciencecollaborator
Biospecimen
atheromas that are being removed from arteries
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- OTHER
- Target Duration
- 3 Years
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- doctor
Study Record Dates
First Submitted
February 4, 2020
First Posted
February 6, 2020
Study Start
May 1, 2020
Primary Completion
May 1, 2020
Study Completion
June 30, 2021
Last Updated
February 6, 2020
Record last verified: 2020-02
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, ICF
- Time Frame
- 2023- forever
only the pthological and clinical findings