NCT04256694

Brief Summary

This is a prospective study seeks to determine how often a rapid antigens test for group A streptococcus is positive in healthy adults

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Feb 2020

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 3, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

February 5, 2020

Completed
Same day until next milestone

Study Start

First participant enrolled

February 5, 2020

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2021

Completed
Last Updated

September 3, 2020

Status Verified

September 1, 2020

Enrollment Period

1.2 years

First QC Date

February 3, 2020

Last Update Submit

September 2, 2020

Conditions

Keywords

Carrier rateRapid antigen test

Outcome Measures

Primary Outcomes (1)

  • % Positive Rapid Antigen Strep Tests

    % of positive rapid antigen strep tests amongst all volunteers

    The throat will be swabbed, and the swab will be immediately analyzed. The results are available after five minutes.

Secondary Outcomes (1)

  • Predictors of Positive Strep Tests

    After enrollment of all subjects, a logistic regression analysis will be performed.

Study Arms (1)

Healthy Adult Subjects

Diagnostic Test: Rapid Antigen Test for Group A Streptococcus

Interventions

Rapid strep tests will be performed by throat swab of healthy adult volunteers.

Healthy Adult Subjects

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Healthy volunteers, primarily from subjects known to the investigators.

You may qualify if:

  • Any person at least 18 years old

You may not qualify if:

  • pregnant
  • prisoners
  • currently taking antibiotics
  • any acute symptoms

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kendall Regional Medical Center

Miami, Florida, 33175, United States

RECRUITING

Related Publications (4)

  • Matthys J, De Meyere M, van Driel ML, De Sutter A. Differences among international pharyngitis guidelines: not just academic. Ann Fam Med. 2007 Sep-Oct;5(5):436-43. doi: 10.1370/afm.741.

    PMID: 17893386BACKGROUND
  • Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010 Sep;126(3):e557-64. doi: 10.1542/peds.2009-2648. Epub 2010 Aug 9.

    PMID: 20696723BACKGROUND
  • Oliver J, Malliya Wadu E, Pierse N, Moreland NJ, Williamson DA, Baker MG. Group A Streptococcus pharyngitis and pharyngeal carriage: A meta-analysis. PLoS Negl Trop Dis. 2018 Mar 19;12(3):e0006335. doi: 10.1371/journal.pntd.0006335. eCollection 2018 Mar.

    PMID: 29554121BACKGROUND
  • Gunnarsson RK, Holm SE, Soderstrom M. The prevalence of beta-haemolytic streptococci in throat specimens from healthy children and adults. Implications for the clinical value of throat cultures. Scand J Prim Health Care. 1997 Sep;15(3):149-55. doi: 10.3109/02813439709018506.

    PMID: 9323783BACKGROUND

Study Officials

  • Tony Zitek, MD

    Kendall Healthcare Group, Ltd.

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Tony Zitek, MD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 3, 2020

First Posted

February 5, 2020

Study Start

February 5, 2020

Primary Completion

April 30, 2021

Study Completion

April 30, 2021

Last Updated

September 3, 2020

Record last verified: 2020-09

Locations