Characterization of Corticospinal Excitability During Progressive Skin Cooling
1 other identifier
interventional
10
1 country
1
Brief Summary
This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Aug 2019
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 22, 2019
CompletedFirst Submitted
Initial submission to the registry
November 26, 2019
CompletedFirst Posted
Study publicly available on registry
February 5, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2022
CompletedDecember 6, 2022
December 1, 2022
2.5 years
November 26, 2019
December 2, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change in Corticospinal Excitability
Motor Evoked Potentials (MEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of Corticospinal excitbaility
at 0, 20, 40, 60 and 90 minutes
Secondary Outcomes (4)
Change in Spinal Excitability
at 0, 20, 40, 60 and 90 minutes
Change in Skin Temperature
at 0, 20, 40, 60 and 90 minutes
Change in Core Temperature
at 0, 20, 40, 60 and 90 minutes
Change in Metabolic Heat Production
at 0, 20, 40, 60 and 90 minutes
Other Outcomes (2)
Change in Peripheral nerve excitability
at 0, 20, 40, 60 and 90 minutes
Change in Maximal Voluntary Contraction of Elbow Flexors
at 0, 20, 40, 60 and 90 minutes
Study Arms (2)
Control Condition
NO INTERVENTIONSubjects will sit at rest wearing a liquid perfused suit containing thermoneutral water for 60 min. The suit will not be turned on during this period.
Cold Condition
EXPERIMENTALSubjects will be cooled for 60-90 min at \~ 4-10°C using a liquid perfused suit. Subjects will then be rewarmed for 30 min at \~ 41°C using the liquid perfused suit.
Interventions
60-90 mins of cooling via a liquid perfused suit circulating \~4-10°C liquid.
Eligibility Criteria
You may qualify if:
- Healthy adult
- Right Handed
- Pass Magnetic Stimulation Safety Checklist
- Pass Medical Screening Questionnaire
You may not qualify if:
- Left Handed
- Any adverse responses to cold exposure (Raynaud's Syndrome)
- Cardiorespiratory Disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
211 Max Bell Centre, University of Manitoba
Winnipeg, Manitoba, R3T 2N2, Canada
Related Publications (1)
Hurrie DMG, Talebian Nia M, Power K, Stecina K, Gardiner P, Lockyer E, Giesbrecht GG. Spinal and corticospinal excitability in response to reductions in skin and core temperatures via whole-body cooling. Appl Physiol Nutr Metab. 2022 Feb;47(2):195-205. doi: 10.1139/apnm-2021-0370. Epub 2021 Sep 28.
PMID: 34582724DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gordon Giesbrecht, PhD
University of Manitoba
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
November 26, 2019
First Posted
February 5, 2020
Study Start
August 22, 2019
Primary Completion
March 1, 2022
Study Completion
June 1, 2022
Last Updated
December 6, 2022
Record last verified: 2022-12
Data Sharing
- IPD Sharing
- Will not share